原发性甲状腺肿瘤中C-myc和垂体肿瘤转化基因-1的表达与临床意义  

Expressions of C-myc and PTTG-1 in primary thyroid tumors and their clinical significance

作　　者：龙尚朝[1] 梁华晟[2] 钟宇华[2] 林华德 黄宇[3] 

机构地区：[1]广西平南县人民医院,537300 [2]广西医科大学第九附属医院内分泌科,广西北海市536000 [3]广西壮族自治区人民医院肝胆腺体外科,南宁市530021

出　　处：《实用医学杂志》2007年第18期2847-2849,共3页The Journal of Practical Medicine

基　　金：广西科技厅自然科学基金资助项目(编号:0339080)

摘　　要：目的:研究原癌蛋白C-myc、垂体肿瘤转化基因-1(pituitary tumor-transforming gene 1,PTTG-1)在原发性甲状腺肿瘤中的表达及其与病变的关系。方法:应用免疫组化方法检测85例原发性甲状腺肿瘤(腺癌42例,腺瘤43例)标本中C-myc、PTTG-1的表达。结果:C-myc及PTTG-1在甲状腺癌表达均高于腺瘤(P<0.01)。C-myc及PTTG-1蛋白表达与腺癌转移(P<0.05及P<0.05)、预后指数(P<0.05及P<0.01)具有相关性。C-myc蛋白表达水平与PTTG-1呈显著正相关(r=0.6028,P<0.01)。结论:检测C-myc及PTTG-1水平对于鉴别原发性甲状腺肿瘤良恶性具有重要参考意义,其表达水平可能是判断甲状腺癌预后的观测指标。Objective To study the expressions of C-myc and pituitary tumor-transforming gene 1 （PTTG-1） in primary thyroid tumors and their relationship with the lesions. Method The expressions of C-myc and PTTG-1 were detected by immunohistochemistry in 85 samples of primary thyroid tumors （42 adenocarcinomas and 43 adenomas）. Results The expressions of C-myc and PTTG-1 were higher in thyroid adenocarcinomas than in adenomas （P 〈 0.01 ）. Both C-myc and PTTG-1 expressions were correlated with metastasis（P 〈 0.05 or P 〈 0.05） and prognostic index （P 〈 0.05 or P 〈 0.01）. The level of C-myc expression was positively related with PTTG-1 （r=-0.602 8,P 〈 0.01 ）. Conclusions Detection of both C-myc and PTTG-1 plays an important role in differentiating malignancy from benignity of thyroid tumors. The levels of C-myc and PTTG-1 may be used as an indicator for predicting the prognosis of thyroid carcinomas.

关 键 词：甲状腺肿瘤 免疫组织化学 C-MYC 垂体肿瘤转化基因-1 

分 类 号：R736.1[医药卫生—肿瘤] R736.4[医药卫生—临床医学]