诺氟沙星中间体及副产物相对含量的HPLC测定  

HPLC DETERMINATION OF RELATIVE CONTENTS OF INTERMEDIATES AND SIDE PRODUCTS OF NORFLOXACIN PREPARATION

作　　者：顾慧儿[1] 陶珍[1] 郭惠元[1] 

机构地区：[1]中国医学科学院中国协和医科大学医药生物技术研究所

出　　处：《中国医药工业杂志》1997年第3期138-140,共3页Chinese Journal of Pharmaceuticals

摘　　要：采用ＨＰＬＣ法测定诺氟沙星中间体及副产物的相对含量，为工艺改进。A reversed phase HPLC method was used for the determination of relative contents of intermediates and side products in the preparation of norfloxacin,the mobile phase was methanol water (65∶35;72∶28),wavelength of the detection was 225 nm.The method was accurate.

关 键 词：高效液相色谱 含量测定 诺氟沙星 中间体 副产物 

分 类 号：TQ463.54[化学工程—制药化工] TQ460.72[医药卫生—药物分析学]