接触室内煤烟的肺癌患者多环芳烃 DNA 加合物的研究  

A Study on Polycyclic Aromatic Hydrocarbon DNA Adduct in Lung Cancer Patients Exposed to Indoor Coal burning Smoke

作　　者：徐坤[1,2,3] 李学明[1,2,3] 胡福定[1,2,3] 陆旭邦 何兴舟[1,2,3] 刘鸿君[1,2,3] 蔡德颜[1,2,3] 蒲志坚 符开伦[1,2,3] 梁曙光[1,2,3] 孔辉[1,2,3] 马冬[1,2,3] 李健学[1,2,3] 

机构地区：[1]昆明市第一人民医院 [2]宣威县人民医院 [3]中国预防医学科学院环境卫生与卫生工程研究所

出　　处：《中华预防医学杂志》1997年第2期95-98,共4页Chinese Journal of Preventive Medicine

基　　金：卫生部科学研究课题基金

摘　　要：本实验是为了探索宣威肺癌病因和肺癌早期危险性评价方法做一点尝试，应用３２Ｐ后标记法检测了宣威３０例（实验组）、昆明１０例（对照组）肺癌病人的纤维支气管镜（纤支镜）刷落细胞的多环芳烃（ＰＡＨ）－ＤＮＡ加合物。结果表明宣威肺癌病人的ＰＡＨ－ＤＮＡ加合物水平远远高于对照组。该结果从分子水平上证明宣威室内煤烟污染与肺癌有直接联系，ＤＮＡ加合物的检测可以作为人群危险性评价的指标。The objective of this study is to explore the etiology and early risk evaluation of lung cancer in Xuanwei County ,Yunnan Province of China. Polycyclic aromatic hydrocarbon (PAH) DNA adduct in brushing cells from fibrobronchoscopy was determined in 30 cases with lung cancer in Xuanwei County and 10 controls in Kunming, Yunnan Province by 32 P postlabelling assay. Results showed that PAH DNA levels in lung cancer patients of Xuanwei County were much more higher than those in controls. It suggested that air pollution caused by indoor coal burning associated directly with the occurrence of lung cancer, and detection of DNA adduct could be used as an indicator for its risk assessment in population.

关 键 词：空气污染 肺肿瘤 DNA加合物 煤烟 多环芳烃 

分 类 号：R734.202[医药卫生—肿瘤]