MTA1蛋白在乳腺癌浸润与转移中作用的研究  

The role of MTA1 protein in the invasion and metastasis of breast cancer

作　　者：李孟圈[1] 鲍俊涛[1] 李靖若[1] 苏静[1] 

机构地区：[1]郑州大学第一附属医院乳腺外科,郑州450052

出　　处：《肿瘤》2007年第8期655-657,共3页Tumor

基　　金：河南省医学高新技术发展扶持资助项目(编号:20060038)

摘　　要：目的：探讨转移相关基因（metastasis-associated gene 1，MTA1）蛋白表达与乳腺癌生物学行为之间的关系。方法：运用免疫组化SP法检测116例乳腺癌组织及配对正常乳腺组织中MTA1蛋白的表达。结果：（1）MTA1蛋白在乳腺癌组织中表达率为70．7％，高于配对正常乳腺组织的10．3％，差异有统计学意义（P〈0．05）。（2）MTA1蛋白在Ⅲ-Ⅳ期、低分化、有腋窝淋巴结转移的乳腺癌组中表达率高于Ⅰ～Ⅱ期、高分化及中等分化癌、无腋窝淋巴结转移组，差异有统计学意义（P〈0．05）。结论：MTA1蛋白高表达与乳腺癌临床分期、组织学分级以及淋巴结转移呈正相关，是一种转移促进蛋白。经进一步研究有可能成为转移复发的参考指标。Objective： To investigate the relationship between metastasis-associated gene 1 （MTA1） expression and the biological behaviors on human breast cancer. Methods： SP immunohistochemical technique was used to detect the expression of MTA1 protein among 116 human breast cancer samples and matched normal breast tissues. Results： （ 1 ）The expression of MTAI was significantly higher in the breast cancer tissues than those of matched normal breast tissues （70.7% vs 10.3%, P 〈0.05）. （2）MTAI protein had significantly higher expression in grade Ill-IV, low-differentiated, and axillary lymph node metastatic breast cancer tissues than those at grade I -I], high or middle differentiated, and without axillary lymph node metastasis （P 〈0.05）. Conclusion： There is a positive association between the expression of MTA1 and clinical stage, histological grade, and lymph node metastasis of breast cancer. MTA1 is a metastasis-facilitated protein and can be used as a prognostic marker for detection of recurrence and metastasis of breast cancer.

关 键 词：乳腺肿瘤 肿瘤转移 基因表达 免疫组织化学 

分 类 号：R737.9[医药卫生—肿瘤] R73-37[医药卫生—临床医学]