ELF方案联合卡铂动脉灌注治疗晚期胃癌临床观察  

Clinical observation on the effect of ELF regimen combined with intra-arterial infusion of carboplatin on advanced gastric carcinoma

作　　者：蒋红良[1] 徐惠亮[1] 王文强[1] 

机构地区：[1]绍兴第二医院肿瘤科,绍兴312000

出　　处：《肿瘤》2007年第8期658-659,662,共3页Tumor

摘　　要：目的:比较ELF方案联合卡铂动脉灌注与静脉滴注对晚期胃癌的治疗效果。方法:58例患者随机分为2组,均用ELF方案联合卡铂,其中动脉灌注28例,静脉滴注30例。结果:动脉灌注组完全缓解率17.86%(5/28),总有效率67.86%(19/28);静脉滴注组完全缓解率3.33%(1/30),总有效率36.67%(11/30)。2组间总有效率差异有统计学意义(2χ=5.64;P<0.05),2组中位生存期分别为10个月和5.5个月,差异有统计学意义(P=0.002)。结论:ELF方案联合卡铂动脉灌注治疗晚期胃癌局控率优于静脉滴注组,是治疗晚期胃癌的一种有效手段。Objective：To compare the effects of ELF regimen combined with intra-arterial or intravenous infusion of carboplatin on advanced gastric carcinoma. Methods： Fifty-eight patients with advanced gastric carcinoma were randomly divided into 2 groups. Twenty-eight patients received ELF regimen with intra-arterial infusion of carboplatin and thirty patients received ELF regimen with intravenous infusion of carboplatin. Results：The complete remission （CR） rate was 17.86% （5/28） and the overall response rate was 67.86% （19/28） for intra-arterial infusion group. The CR rate was 3.33% （1/30） and the overall response rate was 36.67% （ 11/ 30） for intravenous infusion group. The difference in the overall response rate between the two groups was significant （χ^2 = 5.64, P 〈 0.05 ）. The median survival periods were 10 months for intra-arterial infusion group and 5.5 months for intravenous infusion group. The difference was significant （ P = 0.002 ）. Conclusion： The local control rate is significantly higher in intra-arterial infusion group than that of intravenous infusion group. ELF regimen combined with intra-arterial infusion of carboplatin is an effective approach for advanced gastric cancer therapy.

关 键 词：胃肿瘤/药物疗法 化学疗法 肿瘤 局部灌注 ELF方案 药物疗法 联合 

分 类 号：R735.2[医药卫生—肿瘤]