加替沙星与左氧氟沙星眼用凝胶对细菌性结膜炎的疗效比较  

Effects of gel gatifloxacin versus levofloxacin in treatment of bacterial conjunctivitis

作　　者：朱颖[1] 祝肇荣[1] 

机构地区：[1]上海交通大学医学院新华医院眼科,上海200092

出　　处：《上海交通大学学报（医学版）》2007年第8期1003-1005,共3页Journal of Shanghai Jiao tong University:Medical Science

摘　　要：目的评价加替沙星眼用凝胶治疗细菌性结膜炎的临床疗效和安全性。方法采用双盲和随机对照试验设计,以左氧氟沙星眼用凝胶为对照。试验组36眼,对照组36眼。两组给药方法均为1滴/次,3次/d,涂入结膜囊内,疗程均为7 d。结果试验组和对照组的有效率分别为88.89%和91.67%,差异无统计学意义。试验组和对照组的细菌清除率分别为90.48%和93.75%,两组比较无显著性差异。视力及局部用药后耐受性评分在两组之间无显著差异。结论加替沙星眼用凝胶治疗细菌性结膜炎安全有效,有一定的临床应用价值。To assess the clinical effectiveness and safety of gatifloxacin gel to bacterial conjunctivitis. Methods Doubleblind and random selection were designed for the study, with levofloxacin gel as the control medicine. Thirty-six eyes of the experimental group and 36 of the control group were eligible for evaluation. Each eye received the gel one drop a time and three times per day. The gels were applied to the conjunctiva sac for 7 d. Results The clinic effectiveness of experimental group and control group were 88.89% and 91.67% , which indicated no significant difference. Microbial eradication rates were 90.48% and 93.75% , no significant difference either. Safety composite scores were similar between groups. Conclusion Gatifloxacin ophthalmic gel is safe and effective for treatment of bacterial conjunctivitis, and contains certain clinical value.

关 键 词：加替沙星 左氧氟沙星 细菌性结膜炎 双盲随机对照 

分 类 号：R777.3[医药卫生—眼科]