甲胎蛋白在重型肝炎中改变的分析  

The Changes of alpha fetoproteim in patients with severe hepatitis

作　　者：李国钦[1] 高碧华[1] 叶报春[1] 

机构地区：[1]北海市人民医院肝病科,广西北海536000

出　　处：《中西医结合肝病杂志》2007年第4期198-199,共2页Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases

摘　　要：目的：了解重型肝炎患者甲种胎儿球蛋白（AFP）的变化。方法：38例重型肝炎患者，根据临床转归分为存活组和死亡组。入院后动态观察AFP的改变。用放免法检测血清AFP。结果：38例重型肝炎患者的AFP（205．64±289．78）ng／ml，显著高于正常值（8．1ng／m1），P〈0．001。存活组22例患者的AFP（225．03±65．16）ng／ml，显著高于正常值，P=0．003。但是，两组间的AFP差异无显著性意义（P=0．63）。38例重型肝炎中，6例患者的AFP在700～900ng／ml之间，10例在100～500ng／ml之间，其余均高于正常值的2～10倍（尤以存活组较为明显），仅4例在正常值范围之内。结论：重型肝炎有强烈的肝细胞再生现象，肝细胞再生能力对患者的预后有一定影响。Objective： To investigate the changes of alpha fetoprotein （AFP） in patients with severe hepatitis. Methods： Thirty eight patients were divided into two groups-the survival （22 cases） and the dead （16 cases） by clinical inversion. AFP levels were measured with radioimmunoassay （RIA） to observe the changes of AFP in the patients hospitalized. Results： AFP （205.64 ±289. 67） ng/ml in the severe patients was obviously higher than that of the normal （8. lng/ml）, P 〈0. 001. There were no significant difference between the former [ AFP （225.03± 65. 16） ng/ml ] and latter [ AFP （ 178.97 ± 68.48 ）ng/ ml, P =0. 63]. AFP of 6 patients were in 700 -900ng/ml and 10 in 100 -500ng/ml. The others were from twice to 10 times higher than that of the normal and only 4 in normal. Conclusions ： It was showed there was a hepatocellular regeneration strongly appeared in severe heaptitis.

关 键 词：重型肝炎 甲胎蛋白 肝细胞再生 

分 类 号：R575.1[医药卫生—消化系统]