扑热息痛与β-环糊精包合物的热分解动力学和包合结构的研究  

Thermokinetic study and structure investigation on inclusion compound of β-cyclodextrin with acetaminophen

作　　者：李代禧[1] 刘亿淑[2] 张建民[1] 陈正隆[3] 

机构地区：[1]上海理工大学医疗器械与食品学院,上海200093 [2]贵阳中医学院第一附属医院,贵阳550001 [3]台湾中山大学理学院,高雄80424

出　　处：《上海理工大学学报》2007年第4期373-377,共5页Journal of University of Shanghai For Science and Technology

基　　金：国家自然科学基金资助项目(50436030);上海市重点学科建设资助项目(T0503)和(P0502);上海市自然科学基金资助项目(05ZR14088);上海市教委资助项目(05EZ21)

摘　　要：采用饱和溶液法制备了扑热息痛的β-环糊精包合物,并用紫外光谱(UV)、量化计算和非等温热重(TG)分析方法分别研究了该包合物的电子吸收光谱、微观包合结构、热稳定性和分解动力学性质.利用紫外测定验证了包合物的生成和存在;通过Coats-Redfen积分方程和Kissinger方法确定了包合物的最佳热分解机理;结合理论紫外吸收光谱确定了微观包合结构,得到了包合物的稳定能约为54 kJ/mol.The inclusion compound of β-cyclodextrin （13-CD） with Acetaminophen （AAP） was prepared and investigated by means of ultra-violet （UV） spectrum, theoretical calculation and non- isothermal thermogravimetry （TG） with various heating rates. In order to prove the formation of the title inclusion, the UV spectra of the inclusion under various mole ratios of AAP：β-CD are determined. The mechanism of thermal decomposition reaction of the title inclusion compound as well as its kinetics parameters are ascertained by Coats-Redfen＇s integral equation and the Kissinger＇ s method. The results of the thermoanalysis indicate that the optimal kinetic function of the thermal decomposition reaction of the inclusion compound is the Avrami-Erofeev equation with n = 3/4, and the corresponding mechanism is controlled by random nuclear producing and growing process. The real microcosmic structure of the title inclusion was investigated recurring to the contrast the experimental results to theoretical ones of the UV spectra. And at the same time, the stability energy of the inclusion compound was obtained as about 54 kJ/mol by the theoretical calculation .

关 键 词：扑热息痛 Β-环糊精 主-客体相互作用 包合结构 

分 类 号：O642[理学—物理化学]