多发性硬化早期表现为临床孤立综合征79例临床分析  

Clinical Analysis of 79 Clinically Isolated Syndromes at Early Multiple Sclerosis

作　　者：张金妮[1] 杨国宏 李宏增[1] 李柱一[1] 

机构地区：[1]第四军医大学唐都医院神经内科,陕西西安710038 [2]解放军422医院神经内科,广东湛江524005

出　　处：《中国神经免疫学和神经病学杂志》2007年第5期249-252,共4页Chinese Journal of Neuroimmunology and Neurology

摘　　要：目的探讨多发性硬化(MS)早期表现为临床孤立综合征(clinically isolated syndrome,CIS)的临床特点。方法收集96例MS患者发病早期的资料,回顾性分析其中符合CIS的79例患者的临床特点、相关检查、治疗及扩展的功能障碍状况量表评分。结果MS患者早期表现为CIS占82.3%,其中41.1%经MRI检查提示为"多灶性"损害;首次发作后经激素冲击治疗可缓解者占96.1%,其中视神经炎型疗效较显著。结论CIS的临床表现多不典型,详细询问病史、体格检查、常规MRI及诱发电位检查有助于早诊断。早期给予激素冲击治疗可达到有效缓解。Objective To analyze the clinical features of clinically isolated syndromes （CIS） at early multiple sclerosis （MS）. Methods Retrospective analysis included 79 CIS （51women） out of 96 patients with MS, with a median age of 32.0 years and median duration of the disease of 1.0 year. Results In 82.3% of MS patients, onset is a CIS. 41.1% CIS presented with multifocal presentations. Higher dose intravenous corticosteroids hastened the speed and degree of recovery in 96.1% patients with CISs, especially optic neuritis. Conclusions Clinical history, neurologic examination, MRI and evoked potentials tests are primarily helpful in establishing the early diagnosis of CIS. Intravenous corticosteroids are contributed to the rapid recovery of CIS.

关 键 词：临床孤立病灶综合征 多发性硬化 磁共振 诱发电位 EDSS评分 

分 类 号：R744.5[医药卫生—神经病学与精神病学]