Synthesis of 12-alkoxycarbonylmethylene-1,15-pentadecanolides  

作　　者：Jian Jun Li Shu Hui Jin Xiao Mei Liang De Kai Yuan Dao Quan Wang 

机构地区：[1]Key Lab of Pesticide Chemistry and Application Technology, Department of Applied Chemistry, China Agricultural University, Beijing 100094, China

出　　处：《Chinese Chemical Letters》2007年第8期915-916,共2页中国化学快报（英文版）

摘　　要：Six novel 12-alkoxycarbonylmethylene-1,15-pentadecanolides （3） were synthesized from 2-nitrocyclo-dodecanone by the Michael addition with acrolein followed by ring enlargement, Nef reaction and Wittig-Homer reaction. Their structures were confirmed bv 1H NMR, IR and elemental analysis. The preliminary bioassay showed that they have some fungicidal activity.Six novel 12-alkoxycarbonylmethylene-1,15-pentadecanolides （3） were synthesized from 2-nitrocyclo-dodecanone by the Michael addition with acrolein followed by ring enlargement, Nef reaction and Wittig-Homer reaction. Their structures were confirmed bv 1H NMR, IR and elemental analysis. The preliminary bioassay showed that they have some fungicidal activity.

关 键 词：12-Alkoxycarbonylmethylene-1  15-pentadecanolide MACROLIDE Acrylic ester Wittig-Horner reaction Fungicidal actictity 

分 类 号：O624.5[理学—有机化学]