7例转移性透明细胞性肾细胞癌的诊断及鉴别诊断  

Metastatic clear cell renal cell carcinoma:a clinicopathological analysis

作　　者：陆鸣[1] 韦萍[1] 陈书媛[1] 张彦宁[1] 王翠芝[1] 

机构地区：[1]首都医科大学附属北京友谊医院病理科,北京100050

出　　处：《诊断病理学杂志》2007年第4期246-248,共3页Chinese Journal of Diagnostic Pathology

摘　　要：目的描述肺、肾上腺、甲状腺转移性透明细胞性肾细胞癌(RCCs)的病理特点,探讨其诊断及鉴别诊断。方法应用HE和免疫组化方法,对7例转移性透明细胞性RCCs及其中5例的肾原发性癌染色并观察。结果转移性透明细胞性RCCs组织学具有实性巢状、有/无腔的腺泡状及腺管状结构,间质少且富于血管。免疫组化示全部转移性及原发性透明细胞性RCCs表达CD10、CK和vimentin。结论在肿瘤发生部位特异性抗体阴性表达的情况下,结合肿瘤组织学特征,应考虑转移性透明细胞性RCCs。CD10是鉴别转移性透明细胞性RCCs的首选抗体。Objective To describe the pathological features of the metastatic clear cell renal cell carcinomas （RCCs） to the lung, adrenal gland as well as thyroid gland, and to explore the diagnosis and differential diagnoses of metastatic clear cell RCCs. Methods 7 cases of metastatic clear cell RCCs and their 5 cases of primary tumors were studied by hematoxylin and eosin stain and immunohistochemical techniques. Results The predominant histologic pattern of metastatic clear cell RCCs was characterized by the presence of small nest, alveolar, acinar and glandular structures of neoplastic cells separated by a prominent vascular stroma. They might share morphologic similarities with some primary pulmonary adenocarcinoma, adrenalcortical tumors and thyroid clear cell carcinoma. All seven cases of metastatic clear cell RCCs and 5 cases of primary clear cell RCCs showed positive CD10 membranous staining. Conclusion CD10 is a superior marker for distinguishing metastatic clear cell RCCs from the primary carcinoma of lung, adrenal and thyroid gland.

关 键 词：CD10 透明细胞性肾细胞癌 转移瘤 鉴别诊断 

分 类 号：R737.11[医药卫生—肿瘤]