胆囊原发性透明细胞癌临床病理观察  

Primary clear cell carcinomas of gallbladder:a clinicopathologic observation

作　　者：肖方星[1] 罗春华[1] 张玉凤[1] 聂明[1] 郑启忠[1] 

机构地区：[1]厦门市中医院病理科,福建厦门361000

出　　处：《诊断病理学杂志》2007年第4期255-257,共3页Chinese Journal of Diagnostic Pathology

摘　　要：目的探讨胆囊原发性透明细胞癌(CCG)的临床病理特征、诊断及鉴别诊断。方法对1例原发于胆囊的透明细胞癌进行光镜观察,行组织化学及免疫组化染色,并复习文献。结果肿瘤细胞主要由透明细胞构成,少部分为嗜酸性细胞,排列成实性巢状、片状,可见腺管结构。特殊染色和免疫组化显示PAS染色(-),CK7、CK20、CEA和EMA(+),vimenin(-)。结论胆囊原发性透明细胞癌罕见,诊断必须结合病史、全身检查及随访资料,并要排除转移性透明细胞癌。Objective To explore the clinicopathological features and diagnosis of primary clear cell carcinoma of the gallbladder and its differential diagnosis. Methods A case of primary clear cell carcinoma of the gaUbladder was studied with HE stain, histechemieal and immunohistechemical stains and then review of the literature. Results The histopathological features of the tumor were that the tumor was predominantly composed of clear cells and a few eosinophilic cells, which were arranged in solid- nest, sheet and glandular architecture. PAS and immunohistochemieal stains showed that the tumor cells were negative for PAS, vimentin, and positive for CK7, CK20, CEA and EMA. Conclusions Clear cell carcinoma arising in the gallbladder is a extremely rare neoplasm. Diagnosis of primary clear cell careinoma of the gallbladder must be made with combination of patient＇ s history, through physical examination and follow-up data after mesta.static lesions are excluded.

关 键 词：胆囊肿瘤 透明细胞癌 免疫组化 诊断 鉴别 

分 类 号：R735.8[医药卫生—肿瘤]