粘性小管切开术与小梁切除术后角膜内皮细胞变化的临床研究  

The clinical study on the change of corneal endothelial cells after viscocana-lotomy and trabeculectomy

作　　者：蒋燕玲[1] 袁志兰[1] 张为中[1] 张薇玮 李艳[1] 

机构地区：[1]南京医科大学第一附属医院江苏省人民医院眼科

出　　处：《国际眼科杂志》2007年第4期1025-1027,共3页International Eye Science

摘　　要：目的:探讨角膜内皮细胞在粘性小管切开术或小梁切除术后的变化及临床意义。方法:采用非接触眼压计,角膜内皮计及细胞图像分析系统观察16例粘性小管切开术,25例小梁切除术手术前后眼压、中央角膜厚度、角膜内皮细胞情况,并对结果进行统计学分析。结果:粘性小管切开术组术后眼压显著下降(P<0.05),中央角膜厚度(CCT),最小细胞面积(MIN),最大细胞面积(MAX),平均细胞面积(AVE),细胞面积变异系数(CV),细胞密度(CD)均较术前无显著性差异(P>0.05)。小梁切除组术后眼压显著下降(P<0.05),中央角膜厚度(CCT)较术前增加(P<0.05),平均细胞面积(AVE)较术前增加(P<0.05),细胞密度(CD)及六角形细胞百分数(H%)均较术前显著减少(P<0.05)。结论:粘性小管切开术和小梁切除术均可有效控制眼压,粘性小管切开术后角膜内皮细胞变化较小,手术安全性高。AIM： To study the changes of corneal endothelial cells after viscocanalotomy or trabeculectomy and explore its clinical significance. METHODS： Longitudinal observation of 16 viscocanalotomy （VCO） and 25 trabeculectomy （TE） were carried out. The non-contact tonometer was used to measure the intraocular pressure （IOP） before and after the operation respectively, and the TOPCON non-contact specular microscope was used to observe center corneal thickness （CCT） and the condition of corneal endothelial cells. The statistical analysis was performed via using Stata 9.1 under windows system. RESULTS： The intraocular pressure （IOP） in both groups decreased significantly postoperatively （P 〈0.05）, but the center corneal thickness （CCT）, minimum cell area （MIN）, maximum cell area （MAX）, aerage cell area （AVE）, coefficient of variation of average area （CV）, cell density （CD） in viscocanalotomy group （VCO） had no significant changes postoperatively （P 〉0.05）; the center corneal thickness （CCT）, average cell area （AVE） in trabeculectomy group O-E） increased significantly （P 〈0.05）, cell density （CD） and hexagonality （H%） decreased significantly postoperatively （P 〈0.05）. CONCLUSION： Both vJscocanalotomy and trabeculectomy can control intraocular pressure effectively. No obvious changes was observed in corneal endothelial cells after viscocanalotomy. So the surgery had comparatively high security.

关 键 词：粘性小管切开术 小梁切除术 角膜内皮细胞 中央角膜厚度 

分 类 号：R779.6[医药卫生—眼科]