^(18)F-FMISO在肺癌模型小鼠体内的生物分布及PET显像研究  

Biodistribution and PET imaging of ^(18)F-fluoromisonidazole in murine model of lung carcinoma

作　　者：王钰琦[1] 郑昕[1] 周乃康[1] 张锦明[2] 柳曦[1] 张竞[1] 

机构地区：[1]中国人民解放军总医院胸外科,北京100853 [2]中国人民解放军总医院核医学科,北京100853

出　　处：《第三军医大学学报》2007年第18期1794-1796,共3页Journal of Third Military Medical University

摘　　要：目的评价乏氧显像剂18F-硝基咪唑丙醇(18F-FMISO)在肺腺癌动物模型中的诊断价值。方法荷肺腺癌T739小鼠经尾静脉注入18F-FMISO后不同时间(30、60、90、120min)处死,测量18F-FMISO的生物分布,并行PET显像。对照组小鼠在注入18F-氟脱氧葡萄糖(18F-FDG)后行PET显像。结果荷瘤鼠肿瘤PET显像清晰。生物分布研究表明肿瘤有明显的放射性摄取。在肾脏和肝脏有较高的放射性分布。肿瘤对血和肌肉的T/NT比值均大于2。结论肺部恶性肿瘤组织中18F-FMISO摄取高于正常组织,可通过PET清晰显像,为进一步临床应用于肿瘤的乏氧诊断提供了依据。Objective To evaluate the diagnosis value of a hypoxic contrast, ^18F-fluoromisonidazole （ ^18F- FMISO）, in murine model of pulmonary carcinoma. Methods After the injection of ^18F-FMISO into the tail,48 T739 mice bearing the pulmonary adenocarcinoma were sacrificed and divided into 4 groups according different killing times （30, 60, 90 and 120 min）. The biodistribution was measured and PET scanning was performed. Another 8 tumor bearing T734 mice served as control, and PET was carried out after the injection of ^18F-FDG. Results The tumor PET images with ^18F-FMISO were clear. Considerable radioactive uptake on tumor was observed. Higher radioactivity was found in the kidneys and liver. The T/NT ratios of tumor/muscle and tumor/blood were above 2.0. Conclusion The uptake of ^18F-FMISO in pulmonary malignant tissues is higher than that in normal tissues, thus the pulmonary neoplasm can be identified accurately with PET imaging. Our preliminary study provides a basis for further clinical hypoxic diagnose of the tumor.

关 键 词：^18F-FMISO 乏氧显像剂 生物分布 肺部肿瘤 动物模型 

分 类 号：R730.44[医药卫生—肿瘤] R969.1[医药卫生—临床医学]