非小细胞肺癌中E-CD、CD44s和VEGF表达与淋巴结转移关系的研究  

Study on the expression and significance of E-CD,CD44s and VEGF in human non-small cell lung cancer with lymph node metastasis

作　　者：刘卓星 郭其森[2] 贾慧[2] 

机构地区：[1]莱阳市中医院肿瘤科,山东莱阳265200 [2]山东省肿瘤医院内一科,250117

出　　处：《临床肿瘤学杂志》2007年第8期579-582,共4页Chinese Clinical Oncology

摘　　要：目的:研究上皮型钙粘附素(E-CD)、标准型CD44(CD44s)与血管内皮生长因子(VEGF)在NSCLC中的表达与淋巴结转移的关系。方法:应用免疫组化SP法检测53例NSCLC组织中E-CD、CD44s和VEGF的表达情况,并分析上述3项被检测物与淋巴结转移的关系。结果:E-CD在NSCLC组织中的表达显著低于正常肺组织(P<0.01),E-CD表达与淋巴结转移呈负相关(P<0.05);CD44s在NSCLC组织中的表达显著高于正常肺组织(P<0.05),CD44s与淋巴结转移呈正相关,差异有显著性(P<0.05);VEGF在NSCLC组织中的表达显著高于正常肺组织(P<0.05),且与淋巴结转移呈正相关,差异有显著性(P<0.05)。结论:E-CD、CD44s和VEGF在NSCLC中淋巴结转移过程中起重要作用,可作为判断预后的指标及靶向治疗的靶点。Objective： To study expression of epithelia cadhesion （ E-CD）, standardized CD44 （CD44s） and vascular endothelial cell growth factor （VEGF）in non-small cell lung cancer（ NSCLC ） and investigate their relationship with lymph node metastasis. Methods：The expression of E-CD, CD44s,VEGF was retrospectively determined by SP immunohistochemical technique in 53 patients with NSCLC and 12 cases normal lung tissues. Results：The positive expression of E-CD in NSCLC was significantly lower than that in normal tissues （ P 〈 0. 01 ）. The positive expressions of E-CD was significantly inversely correlated with the lymph node metastasis （ P 〈 0. 05 ）. The positive expression of CD44s and VEGF in NSCLC was significantly higher than that in normal lung tissues（ P 〈 0. 05 ）, respectively. The expression of CD44s in normal tissue was negative. The positive expression of CD44s in with or without lymph node metastasis group was significant different （ P 〈 0. 05 ）. The expression of VEGF was significantly correlated with lymph node metastasis （P 〈0. 05）. Conelusion：E-CD,CD44s and VEGF play important roles in the process of soakage and metastasis of NSCLC. To study the expression of E-CD,CD44s and VEGF in NSCLC could contribute to evaluate prognosis and targeting treatment of NSCLC.

关 键 词：上皮型钙粘附素 标准型CD44 血管内皮生长因子 非小细胞肺癌 

分 类 号：R734.2[医药卫生—肿瘤]