三氧化二砷注射液治疗复发难治性恶性淋巴瘤的临床研究  

Clinical study of arsenic trioxide for patients with malignant lymphoma

作　　者：黄勇[1] 秦叔逵[1] 王琳[1] 杨宁蓉[1] 陈映霞[1] 钱军[1] 何泽明[1] 

机构地区：[1]解放军八一医院全军肿瘤中心内科,南京210002

出　　处：《临床肿瘤学杂志》2007年第8期598-600,共3页Chinese Clinical Oncology

摘　　要：目的:观察三氧化二砷注射液(亚砷酸,As2O3)治疗恶性淋巴瘤的有效性及安全性。方法:全组共23例,其中男性15例,女性8例;年龄15～71岁,中位年龄48岁;入组前病程为11～94月;非霍奇金氏淋巴瘤(NHL)22例,霍奇金氏淋巴瘤(HD)1例,既往均曾接受过3种或以上方案联合化疗,入组后应用As2O3注射液10mg/m2,加入5%葡萄糖或0.9%氯化钠注射液500ml中,静脉缓慢滴注4小时,每天1次,连用14天,3周为1周期,如未出现病情进展或严重毒性反应,则继续应用本方案化疗。2周期后按WHO标准评价近期疗效和毒性反应。结果:全组共接受了74周期治疗,每例1～11周期,平均3.2周期。可评价疗效21例,获CR3例(14.3%),PR10例(47.6%),SD5例(23.8%),PD3例(14.3%),有效率(RR)为61.9%(13/21);疾病进展时间(TTP)为1～4个月,中位TTP3.1个月。常见毒性反应为骨髓抑制,1例Ⅳ度肾毒性死亡。结论:As2O3注射液治疗恶性淋巴瘤有较好的疗效,且毒性反应可以控制,值得临床推广使用。Objective：To evaluate the efficacy and toxicity of arsenic trioxide for patients with malignant lymphoma. Methotis ： arsenic trioxide 10mg/m^2, infused 4 hours, every day, for 2weeks, retreat after 1 weeks that was one cycle consisted of 3 weeks. WHO crieerias were used to evaluation. Results：Twenty-three patients were enrolled in this study. Gross efficiency rate was 61.9% with 3 cases CR and 10 cases PR. The median TIP was 3.1 months. Toxic effects can be controlled. Conclusion：Arsenic trioxide for patients with malignant lymphoma had better effective and less toxic effects.

关 键 词：三氧化二砷 恶性淋巴瘤/难治性 治疗 

分 类 号：R730.53[医药卫生—肿瘤]