艾易舒注射液联合化疗治疗非小细胞肺癌临床疗效观察  

Clincical observation of Aiyishu injection combined with chemotherapy in nonsmall-cell lung cancer

作　　者：汤福良[1] 张海平[1] 

机构地区：[1]上海市肺科医院,上海200433

出　　处：《中国医药导报》2007年第09Z期46-47,共2页China Medical Herald

摘　　要：目的:观察斑蝥酸钠维生素B6注射液(艾易舒)对晚期肺癌患者化疗的协同治疗作用。方法:60例患者随机分为两组,治疗组30例,应用艾易舒合并化疗;对照组30例,单用化疗,比较两组抗肿瘤疗效、临床症状变化、化疗不良反应的发生情况。结果:治疗组30例,抗肿瘤有效率为40%,对照组30例,抗肿瘤有效率为33.3%;治疗组的症状改善率为86.7%,对照组的症状改善率为53.3%;治疗组KPS评分增高率为50.0%,对照组KPS评分增高率为23.3%;治疗组白细胞减少和消化道反应发生率分别为:30.0%、23.3%,对照组白细胞减少和消化道反应发生率分别为:46.7%、43.3%。结论:斑蝥酸钠维生素B6注射液具有增强化疗疗效、改善患者症状、减少化疗毒副反应的作用。Objective： to investigate the synergetic effect of disodium cantharidinate and vitamin B6 injection （Aiyishu） in combination with chemotherapy in the patients with advanced stage lung cancer. Methods： 60 patients were randomized to two groups： Group 1 received Aiyishu injection plus chemotherapy and group 2 received chemotherapy alone. The response rate, the change of clinical symptoms and the adverse effects of anti-cancer therapy were evaluated in patients of two groups. Results： The response rate was 40% and 33.3% in group 1 and 2 respectively; the clinical symptoms improved in 86.7% patients in group 1, compared with only 53.3% in group 2; the KPS score of 50% of patients in group 1 increased, compared with 23.3% in group 2; the incidence rates of leucopenia and gastrointestinal disturbance were 30.0% and 23.3% respectively in patients of group 1, whereas the rates were 46.7% and 43.3%, respectively, in group 2. Conclusion： The disodium cantharidinate and vitamin B6 injection plays important roles in strengthening chemotherapy efficacy, improving symptoms and alleviating adverse effects of chemotherapy.

关 键 词：艾易舒注射液 化疗 非小细胞肺癌 

分 类 号：R734[医药卫生—肿瘤]