EGFR在结直肠癌组织中的表达及其临床意义  

Expression of epidermal growth factor receptor in colorectal cancer and its clinical implications

作　　者：李月敏[1] 徐建明[2] 廖国清[1] 李晓兵[3] 王岩[2] 李明颖[2] 曹阳[2] 李志强[2] 葛飞娇[2] 

机构地区：[1]解放军总医院附属第二医院肿瘤内科,北京100091 [2]军事医学科学院附属307医院全军肿瘤中心,北京100071 [3]军事医学科学院附属307医院病理科,北京100071

出　　处：《中国肿瘤生物治疗杂志》2007年第4期377-380,共4页Chinese Journal of Cancer Biotherapy

基　　金：军队医学科研"十一五"攻关项目(06G140)~~

摘　　要：目的:检测表皮生长因子受体(epidermal growth factor receptor,EGFR)在结直肠癌组织中的表达情况,分析其表达水平与各种主要临床病理学预后因子及长期生存的关系。方法:选取解放军307医院和301医院第二附属医院64例结直肠癌患者的石腊包埋肿瘤标本,以免疫组化方法检测结直肠癌肿瘤标本中EGFR的表达。通过单因素分析和多因素分析判断EGFR表达与临床病理学指标之间的关系;通过多因素分析(COX模型)判断EGFR表达水平与患者总生存期的关系。结果:所有患者肿瘤组织EGFR的阳性表达率为69%。T3期肿瘤EGFR阳性表达明显多于T1和T2期(P<0.05),淋巴结转移阳性者EGFR阳性表达明显多于无转移者(P<0.05),有远处转移者EGFR阳性表达明显多于无远处转移者(P<0.05);EGFR表达与患者性别、年龄、肿瘤原发部位、肿瘤大小、肿瘤分化程度等均无明显相关性。EGFR表达水平与患者总生存期无明显相关。结论:结直肠癌组织EGFR的表达与肿瘤TNM分期相关,与患者总生存期无明显相关。Objective： To detect the expression of epidermal growth factor receptor （EGFR） in colorectal cancer and to evaluate the relationship between EGFR expression with different clinicopathological factors influencing patients＇prognosis and the long term survival of patients. Methods： Immunohistochemistry method was used to detect the expression of EGFR in paraffin-embedded tumor samples from 64 colorectal carcinoma patients, who were treated in No 307 Hospital of PLA and the 2nd Affiliated Hospital of No. 301 Hospital of PLA. Univariate analysis and multivariate analysis were used to study the relationship between EGFR expression and different clinicopathological parameters; Cox regression model was used to assess the relationship between EGFR expression with overall survival period of patients. Results： The positive rate of EGFR was 69%. T3 tumor samples had significantly higher expression of EGFR compared with those of T1 and T2 tumor samples （P 〈 0. 05 ）. EGFR expression in patients with lymphatic metastasis and distant metastasis was significantly higher than that without lymphatic or distant metastasis （ both P 〈 0. 05 ）. No relationship was found between EGFR expression with patients ＇age, gender, primary tumor location, tumor size and degree of histological differentiation, and overall survival. Conclusion ： EGFR expression in colorectal cancer tissues is associated with TNM stage of tumors, but is not associated with overall survival of patients.

关 键 词：结直肠癌 表皮生长因子受体 TNM分期 预后 

分 类 号：R730.5[医药卫生—肿瘤]