Effect of neoadjuvant chemotherapy on locally advanced cervical cancer by internal iliac arterial infusion  

作　　者：Chen Aiping Ding Zhaoxia Xu Bing Zhao Shuping Dai Shuzhen 

机构地区：[1]Department of Gynecology, the Affiliated Hospital, Medical Colledge of Qingdao University, Qingdao 266003 [2]Department of Gynecology, the Eighth People＇s Hospital of Qingdao

出　　处：《现代妇产科进展》2007年第7期558-560,共3页Progress in Obstetrics and Gynecology

摘　　要：Objective:To evaluate the effect of preoperative chemotherapy on locally advanced cervical cancer by internal iliac arterial infusion.Methods:Sixty two patients with bulky or locally advanced cervical cancer from 1999 to 2004 were underwent internal iliac arte- rial infusion chemotherapy by using Seldinger technique.Combined regimens were applied in- cluding cisplatin as the major drug.Two weeks later,all patients received radical hysterectomy. Results:The local tumor regression rate was 93.55%.Postoperative pathologic examination showed that no cervical tumor residue in stumps were found in 61 of 62 patients who underwent radical hysterectomy.Large quantity of necrotic tissue appeared on primary tumor.In 16 patients with positive lymph nodes,15 demonstrated necrotic lymph nodes.Conclusion:Internal iliac ar- terial infusion chemotherapy could effectively reduce tumor volume,increase surgical success rate and decrease lymph nodes and subclinical metastasis rates.Objective：To evaluate the effect of preoperative chemotherapy on locally advanced cervical cancer by internal iliac arterial infusion. Methods： Sixty two patients with bulky or locally advanced cervical cancer from 1999 to 2004 were underwent internal iliac arterial infusion chemotherapy by using Seldinger technique. Combined regimens were applied ineluding cisplatin as the major drug. Two weeks later, all patients received radical hysterectomy. Results： The local tumor regression rate was 93.55%. Postoperative pathologic examination showed that no cervical tumor residue in stumps were found in 61 of 62 patients who underwent radical hysterectomy. Large quantity of necrotic tissue appeared on primary tumor. In 16 patients with positive lymph nodes, 15 demonstrated necrotic lymph nodes. Conclusion：Internal iliac arterial infusion chemotherapy could effectively reduce tumor volume, increase surgical success rate and decrease lymph nodes and subclinical metastasis rates.

关 键 词：子宫癌 灌输 子宫动脉灌注化疗 抑癌基因 凋亡及耐药性影响机制 

分 类 号：R737.33[医药卫生—肿瘤]