5-氟尿嘧啶高分子缓释剂在兔眼滤过术后抗瘢痕形成的研究  

Injectable bioerodible polymer with 5-fluorouracil used in filtration surgery in rabbits

作　　者：徐岩[1] 杨国华[1] 靳伟民[1] 陈克谦[1] 李建新[1] 

机构地区：[1]河南省眼科研究所

出　　处：《中华眼科杂志》1997年第3期184-188,共5页Chinese Journal of Ophthalmology

基　　金：河南省科技攻关基金

摘　　要：目的研究５－氟尿嘧啶（５－ｆｌｕｏｒｏｕｒａｃｉｌ，５－Ｆｕ）缓释剂在兔眼滤过术后抗瘢痕形成的疗效及毒性。方法对２３只家兔双眼行巩膜后唇咬切术，术后次日第１组结膜下注射２．５％５－Ｆｕ缓释剂１０ｍｇ，第２组结膜下注射２．５％５－Ｆｕ注射液１０ｍｇ。术后第１周隔日用药１次，连续３次；第２周隔２日用药１次，连续３次。第３组用同法注射等体积的空白缓释剂。结果空白缓释剂组的滤过泡在术后７天内失败，５－Ｆｕ注射液组的滤过泡在术后２０～３０天失败，５－Ｆｕ缓释剂组的滤过泡持续至实验全程。术后７～３０天，５－Ｆｕ缓释剂组巩膜瘘道的阻塞率为６．７％，５－Ｆｕ注射液组为４１．７％，空白缓释剂组为１００．０％。５－Ｆｕ缓释剂组３只眼，５－Ｆｕ注射液组８只眼及空白缓释剂组２只眼出现角膜上皮缺损。结论本研究结果显示，５－Ｆｕ缓释剂可有效防止滤过泡瘢痕化及巩膜瘘道阻塞，提高兔眼滤过术的成功率，并降低５－Ｆｕ注射液的毒性，有临床应用价值。Objictive A prospectiver and omized and placebo controlled study was performed to evaluate the effect and toxicity of injectable bioerodible polymer with 5 fluorouracil (5 Fu)on the filtra tion surgery in rabbits.Methods Posterior lip sclerectomies were performed on both eyes of 23 rabbits.Injectable bioerodible polymer impregnated with 2.5% 5 Fu 10mg was injected subconjunctivally in 16 eyes,and 2.5% 5 Fu 10mg was injected subconjunctivally in 14 eyes every other day for three times in the first week and every two days for three times in the second week post operatively.Another 16 eyes received the drug free polymer after surgery and served as controls.Results The bleb in the eyes treated with drug free polymer failed in the postoperative 7 days and the bleb in the eyes treated with 5 Fu injection failed in 20 30 days,while the bleb in the eyes treated with 5 Fu polymer remained suc cessful throughout the experimental period.From 7 to 30 postoperative days,the rate of scleral fistula occlusion was 6.7% in the eyes treated with 5 Fu polymer,41.7% in the eyes treated with 5 Fu injec tion and 100% in the eyes treated with drug free polymer.Corneal epithelial defects appeared in 3 eyes treated with 5 Fu polymer,in 8 eyes treated with 5 Fu injection and in 2 eyes treated with drug free polymer.Conclusion Injectable bioerodible polymer with 5 Fu symay significantly prevent bleb scarring and subsequent blockage of the filtering tract,enhance success rate of filtering surgery in rabbits and re duce the to xicity of 5 Fu.This drug delivery system has considerable value for clinical use.

关 键 词：氟尿嘧啶 青光眼 抗瘢痕形成 外科手术 滤过术 

分 类 号：R779.6[医药卫生—眼科]