中国南方汉人骨肉瘤的 HLA 分型  

HLA PHENOTYPES OF OSTEOSARCOMA IN SOUTH CHINA HAN NATIONALITY

作　　者：张伟滨[1,2,3] 沈才伟 杨钰琴[1,2,3] 董建中 蔡体栋[1,2,3] 

机构地区：[1]上海第二医科大学附属瑞金医院骨科 [2]上海市伤骨科研究所 [3]上海第二医科大学免疫学研究所

出　　处：《肿瘤》1997年第3期148-150,共3页Tumor

摘　　要：目的本文比较２２例中国南方汉人典型骨肉瘤患者与２５０例健康中国南方汉人的ＨＬＡ┐Ａ、┐Ｂ、┐ＤＲ、┐ＤＱ各位点抗原出现频率。方法测定７个ＨＬＡ┐Ａ，１７个ＨＬＡ┐Ｂ，１０个ＨＬＡ┐ＤＲ，三个ＨＬＡ┐ＤＱ抗原分型。结果病例组ＨＬＡ┐Ｂ３５位点抗原出现频率为０．３１８，正常对照组为０．０４８，统计结果显示含ＨＬＡ┐Ｂ３５位点抗原的中国南方汉人骨肉瘤发病的相对危险率是无此位点抗原者的９．２３２倍，校正Ｐ值为３．５３６×１０－３（Ｐ＜０．０１）。结论ＨＬＡ┐Ｂ３５位点抗原可能联锁着中国南方汉人骨肉瘤发病的易感性基因。Objective:The frequency of HLA A, B, DR,DQ antigens were tested in 22 South China Han nationality patients suffered with osteosarcoma and in 250 healthy South China Han people Methods:Seven HLA A antigens,17 B antigens,10 DR antigens and 3 DQ antigens were tested Results:The frequency of HLA B35 in patients group is 0 318,but is 0.048 in control group Statistical result showed that the relative risk of suffering osteosarcoma in South China Han people with HLA B35 is 9,232 times than those without HLA B35.Adjusted P value is 3 536×10 -3 ( P <0 01).Conclusions: The susceptibility gene of osteosarcoma may be linked with HLA B35 in the South China Han nationality people

关 键 词：骨肉瘤 人白细胞抗原 中国南方 

分 类 号：R738.102[医药卫生—肿瘤]