胃肠道类癌组织中胃泌素、生长抑素等表达与淋巴结转移相关性的研究  

The correlation between the expressions of gastrin,somatostatin and the metastasis of lymph node in gastrointestinal carcinoid

作　　者：张淑杰[1] 王瑞芬[1] 王正彩[1] 刘明[1] 王立峰[1] 

机构地区：[1]哈尔滨医科大学第一临床医学院病理科,黑龙江哈尔滨150001

出　　处：《哈尔滨医科大学学报》2007年第4期356-358,共3页Journal of Harbin Medical University

基　　金：黑龙江省教育厅科学技术研究项目(10551205);黑龙江省科学技术攻关项目(GB06C40203)

摘　　要：目的探讨胃肠道类癌组织胃泌素、生长抑素、5-羟色胺、胰高血糖素的表达及其临床意义。方法应用免疫组化SP法对36例消化道类癌组织中4种激素蛋白的表达进行检测。结果36例类癌组织中胃泌素表达的阳性率随肿瘤组织分化程度的降低而上升(P<0.05),并与肿瘤的淋巴结转移有相关性(P<0.05);生长抑素的表达与肿瘤的分期相关,在淋巴结转移的肿瘤中表达率显著降低(P<0.01);5-羟色胺、胰高血糖素的表达与肿瘤的分化和淋巴结转移无相关性(P>0.05)。结论胃泌素、生长抑素可能与细胞膜上相应受体结合,促进或抑制肿瘤细胞增殖。对胃泌素、生长抑素等激素蛋白的检测可用来预测类癌的生物学行为。Objective To investigate the expressions of 5-HT, glueagon, somatostatin and gastrin in gastrointestinal carcinoid and its clinical significance. Methods Immunohistochemistry SP method was used to examine the expressions of the four hormonal proteins in 36 cases of gastrointestinal carcinoid. Results The positive rates of the gastrin increased in the poor differentiated gastrointestinal carcinoid tissues （ P 〈 0.05 ）. The expression of gastrin was related to the metastasis of lymph node in gastrointestinal earcinoid tissues（ P 〈 0.05）. The expression of the somatostatin was associated with the stage of tumor, the positive rates of somatostatin decreased in the lymph node metastasis of gastrointestinal earcinoid （ P 〈 0.01 ）. 5-HT and glueagon had no correlation with the differentiation and lymph node metastasis of earcinoid（ P 〉 0.05）. Conclusion When gastrin and somatostatin combine with the membrane receptor of cell, they can stimulate or inhibit the proliferation of the tumor cells. These data indicate that the hormonal proteins may be valuable markers to predict the biologic behavior and prognosis in gastrointestinal carcinoid.

关 键 词：胃肠道类癌 胃泌素 生长抑素 5-羟色胺 胰高血糖素 

分 类 号：R735[医药卫生—肿瘤]