魔芋葡甘聚糖结构改性及其生物学特性在组织工程复合材料中的作用  

Structural modification and biological characteristics of konjac glucomannan in tissue engineering composite scaffold

作　　者：景森[1] 张峰[1] 陈庆华[1] 潘兴华[2] 庞荣清[2] 

机构地区：[1]昆明理工大学材料与冶金工程学院,云南省昆明市650093 [2]解放军成都军区昆明总医院医学实验科,云南省昆明市650032

出　　处：《中国组织工程研究与临床康复》2007年第35期7053-7056,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

基　　金：中国意大利政府合作项目(2005GH22)~~

摘　　要：学术背景:葡甘聚糖是魔芋块茎中所含的储备性多糖,具有很高的黏度,良好的吸水、保湿、成膜、增稠性、凝胶性和一定的生物活性,可作为一种新型的生物材料应用于组织工程领域。目的:介绍魔芋葡甘聚糖的结构、生物学特性、改性现状及其在组织工程领域的研究进展。检索策略:由第一、二作者应用计算机检索Proquest和Elsevier数据库1992-01/2007-04相关文献,检索词为"konjac glucomannan",限定语言种类为"English";同时检索维普数据库、万方数据库1995-01/2007-04相关文献,检索词为"葡甘聚糖",限定语言种类为中文。纳入标准:文章内容与葡甘聚糖的结构、改性研究、生物学特性有关。排除标准:较陈旧的文献和重复研究。文献评价:共收集到65篇相关文献,30篇文献符合标准,其中6篇是综述和述评类文献,其余24篇为基础研究。30篇中9篇介绍葡甘聚糖的结构和生物活性,21篇关于葡甘聚糖的改性和在组织工程领域中的应用。资料综合:①魔芋葡甘聚糖具有特殊的分子结构和生物活性。②魔芋葡甘聚糖的化学改性及其复合改性已经取得了一定的进展,实现了材料间的优势互补作用。③以魔芋葡甘聚糖为基的复合膜,具备作为组织工程支架的性能和结构。结论:利用魔芋葡甘聚糖为高分子多孔前驱体和强韧性增强网络,有望制备出皮肤和骨的理想组织工程支架材料。BACKGROUND： Konjac glucomannan （KGM）, as one kind of reserved polysaccharides, presents high viscosity, good hydroscopicity, favorable moisture retention, film forming property, thickening performance, gel property and bioactivity, so it can be applied as a new type biomaterial of tissue engineering. OBJECTIVE： A brief review was given concerning the structure and bioactivity of KGM, the advancement in the research of chemical modification and tissue engineering. RETRIEVE STRATEGY： The articles published between January 1992 and April 2007 was searched by the first and the second authors in Proquest and Elsevier database on computer with the key words ＂konjac glucomannan＂, and language was restricted to English. Meanwhile, the relevant articles in Chinese were retrieved from Weipu database and Wanfang database published between January 1995 and April 2007, with the same items. Inclusive criterion： the articles related to structure, bioactivity and modification of glucomannan. Exclusive criterion： outdated literatures and repetitive studies. LITERATURE EVALUATION： Totally 65 relevant articles were selected and 30 of them met the inclusive criterion, including 6 reviews and appraisals while other 24 ones were basic study. As for the content, 9 of 30 articles introduced the structure and bioactivity of glucomannan and other 21 referred to the modification and application of glucomannan on tissue engineering. DATA SYNTHESIS： ① KGM has a special molecular structure and bioactivity.② Chemical and composite modification of KGM have made some progresses and achieve complementary advantages between materials.③ KGM-based composite membrane appears the performance and structure of tissue engineering scaffold. CONCLUSION： KGM can be utilized for porous polymer precursor and enhance the toughness network, it is expected to be used as ideal scaffolds for skin and bone tissue engineering.

关 键 词：魔芋葡甘聚糖 组织工程 结构 改性 生物活性 

分 类 号：R318[医药卫生—生物医学工程]