新参数（F／T）／PSAD对PSA在4～10ng／ml区间前列腺癌诊断价值  

The Effect of Percentage of Free Prostate Specific Antigen/Prostate Specific Antigen Density in the Diagnosis of Prostate Cancer of PSA Level in 4 - 10ng/ml

作　　者：燕东亮[1] 胡恩平[1] 张海涛[1] 周岩[1] 刘晟[1] 蔡海荣[1] 章雷[1] 

机构地区：[1]浙江省台州市立医院泌尿外科,318000

出　　处：《医学研究杂志》2007年第9期63-65,共3页Journal of Medical Research

基　　金：浙江省医药卫生科研基金(2006A123);浙江省台州市科技局科研基金(061KY22)

摘　　要：目的评价前列腺特异抗原（PSA）新参数（F／T）／PSAD对血清PSA在4～10ng／ml区间的前列腺癌（PCa）的诊断价值。方法选取经直肠B超引导下前列腺多点穿刺活检血PSA测值在4～10ng／ml的88例患者，其中确诊PCa患者21例，BPH患者67例。比较分析F／T比值、PSAD、（F／T）／PSAD在设定的各阈值范围内，对PCa诊断的敏感度及特异度。结果Pca患者的（F／T）／PSAD）均值明显低于BPH患者（P〈0．001）。F／T比值、PSAD、（F／T）／PSAD在设定的各阈值范围内诊断PCa的敏感度分别为66．67％，76．19％和85．71％；特异度分别为41．79％，43．28％和68．66％。（F／T）／PSAD诊断PCa的特异度有显著优势（P〈0．05）。结论应用（F／T）／PSAD能有效提高PSA在4～10ng／ml区间的PCa检出率，有效减少不必要的穿刺活检。Objective To investigate the usefulness of percentage of free prostate specific antigen（ FPSA/TPSA）/PSA density[ （ F/ T）/PSAD ] in the diagnosis of prostate cancer of PSA level in 4 - 10ng/ml, Methods 88 patients of PSA level in 4 - 10ng/ml were carried out transrectal ultrasound guided prostate biopsy. Among them,21 patients were proved to be suffering from prostate cancer,and other 67 patients were identified as benign prostate hypertrophy. The effect of F/T ratio, PSAD and（ F/T）/PSAD in the diagnosis of prostate cancer were investigated. Results The mean value of（F/T）/PSAD of prostate cancer were significantly lower than benign prostate hypertrophy for patients with PSA levels in 4.0 -10ng/ml, This difference has arrived statistical significance（P 〈 0. 05 ）. At the cut- off values of 0. 16 for F/T ratio and 0. 15 for PSAD and 0. 8 for （ F/T）/PSAD, the sensitivity were 66.67% ,76.19% ,85. 71% ;and specificity 41.79% ,43.28% ,68.66% respectively, Conclusions These results indicated that （F/T）/PSAD could also be an excellent biopsy indicator, provided higher specificity for diagnosing prostate cancer with PSA levels in 4.0 - 10ng/ml than F/T or PSAD , and could reduce the rate of unnecessary prostate biopsy effectively.

关 键 词：前列腺癌 前列腺特异抗原 穿刺活检 

分 类 号：R737.250.4[医药卫生—肿瘤]