同型半胱氨酸与颈动脉粥样硬化及脑梗死关系的探讨  

The relationship between homocysteine and carotid artherosclerosis in cerebral infarction patients

作　　者：沈媛[1] 余华峰[1] 陆伯华[2] 文江平[3] 荣雪余[4] 

机构地区：[1]首都医科大学附属北京同仁医院神经内科,100730 [2]北京市普仁医院神经内科 [3]首都医科大学附属北京同仁医院生化科,100730 [4]首都医科大学附属北京同仁医院B超室,100730

出　　处：《北京医学》2007年第9期543-545,共3页Beijing Medical Journal

摘　　要：目的探讨同型半胱氨酸(Hcy)与颈动脉粥样硬化及脑梗死之间的关系。方法观察90例脑梗死患者和40例对照者,用循环酶法测定血清Hcy水平,用彩色多普勒超声检查颈动脉颅外段。采用非条件Logistic回归分析颈动脉粥样硬化的危险因素及与脑梗死的关系。结果脑梗死组Hcy浓度为22.32(17.05～27.18)μmol/L,显著高于对照组的12.71(9.63～16.48)μmol/L(P﹤0.001),颈动脉粥样硬化与脑梗死相关;校正了传统危险因素后,Hcy仍然与颈动脉粥样硬化相关。结论血清Hcy升高可能通过促进颈动脉粥样硬化,导致脑梗死的形成。To investigate the relationship between homocysteine （Hey） level and carotid artherosclerosis in cerebral infarction patients. Methods In 90 cerebral infarction patients and 40 healthy controls, serum homocysteine level was measured by cyclophorase assay, carotid artherosclerosis was determined by the use of the duplex ultrasonography. Logistic regression was performed to analyze the relationship between homocysteine, carotid artherosclerosis and cerebral infarction. Results The fast homocysteine level in the patient group was 22.32（17.05-27.18）μmol/L, significandy higher than that in the control group 12.71 （9.63-16.48）lμmol/L （P 〈 0.001）;carotid artherosclerosis was related to cerebral infarction; homocysteine level was related to the carotid artherosclerosis and cerebral infarction even after controlling for other traditional risk factors. Conclusions Serum homocysteine is the independent risk factor for cerebral infarction,and artherosclerosis is the probable linkage.

关 键 词：脑梗死 颈动脉粥样硬化 同型半胱氨酸 

分 类 号：R743.33[医药卫生—神经病学与精神病学]