西酞普兰与帕罗西汀治疗焦虑症对照研究  

Comparative Study on Citalopram and Paroxetine in the Treatment of Anxiety Neurosis

作　　者：罗国宏[1] 冯一平[1] 刘国清[1] 

机构地区：[1]南充市精神卫生中心,四川南充637000

出　　处：《川北医学院学报》2007年第5期452-453,共2页Journal of North Sichuan Medical College

摘　　要：目的探讨西酞普兰对焦虑症的临床疗效和不良反应。方法将住院患者72例随机分为两组,分别给予西酞普兰和帕罗西汀治疗,疗程4周。采用Hamilton焦虑量表(HAMD)和副反应量表(TESS)评价临床疗效和不良反应。结果西酞普兰组在治疗第1、2、3周末HAMD评分显著低于帕罗西汀组(p<0.05)。治疗4周时两组临床疗效相似。两组不良反应均轻微。结论西酞普兰是一种安全有效的抗焦虑药,起效更快。Objective To compare the efficacy and safety of citalopram in the treatment of anxiety neurosis.Methods 72 out-patients and in-patients were divided into two groups,treated with citalopram and paroxetine respectively for 4 weeks.Hamilton anxiety scale （HAMD）and the side effects were assessed by the treatment emergent symptom scale （TESS）. Results Scores of HAMD was significantly lower in citalopram group than those in paroxetine group in 1 and 2 weeks after treatment （p〈0.05）.Both groups were similar in curative effect at the end of treatment.Side effects in both groups were mild.Conclusion Citalopram was safe and effective in the treatment of anxiety and had faster efficacy.

关 键 词：西酞普兰 帕罗西汀 焦虑症 

分 类 号：R749.72[医药卫生—神经病学与精神病学]