除草剂解毒剂N-二氯乙酰基-2-甲基-1-氧杂-4-氮杂-螺[4.4]壬烷的合成  

Synthesis of Antidote of N-Dichloroacetyl-2-methyl-1-oxa-4-aza-spiro-4.4-nonane

作　　者：毕洪梅[1] 张金艳[1] 梁英[1] 沈勇[1] 

机构地区：[1]黑龙江八一农垦大学文理学院,黑龙江大庆163319

出　　处：《农药》2007年第9期602-603,606,共3页Agrochemicals

基　　金：黑龙江省教育厅科学技术研究项目(10551229)

摘　　要：以33%的氢氧化钠水溶液为缚酸剂,异丙醇胺、环戊酮和二氯乙酰氯为原料,采用"一锅法"合成了N-二氯乙酰基-2-甲基-1-氧杂-4-氮杂-螺[4.4]壬烷,采用正交实验法得到最佳反应条件:反应原料摩尔比为1∶1∶1.2,苯作溶剂,反应的温度为-15℃～-10℃,搅拌时间为3h,产率达到50.0%。并采用UV、IR、1HNMR和MS对该化合物的结构进行了表征。N-Dichloroacetyl-2-methyl-1-oxa-4-aza-spiro-4.4-nonane was synthesized by one pot method with isopropanolamine,cyclopentanone and dichloroacetyl chloride. The optimum reaction conditions obtained are as follows￡othe proportion in moles of the above materials is 1∶ 1∶1.2,reaction solvent is toluene,reaction temperature is -15 to -10 ℃,reaction time is 3 h,under the optimum condition,the yield of the compound is 50.0%. Its structure was characterized by UV,IR,1H NMR and MS.

关 键 词：N-氯乙酰基-2-甲基-1-氧杂-4-氮杂-螺[4.4】壬烷 解毒剂 合成 

分 类 号：TQ457[化学工程—农药化工]