盐酸甲氯芬酯治疗急性脑出血的疗效评价  

The clinical efficacy of meclofenoxate hydrochloride in treatment of patients with acute intracerebral hemorrhage

作　　者：陆磊[1] 孙晓江[1] 张进[1] 薛波[1] 施弘[1] 

机构地区：[1]上海交通大学附属第六人民医院神经内科,上海200233

出　　处：《药学服务与研究》2007年第4期271-273,共3页Pharmaceutical Care and Research

摘　　要：目的:评价盐酸甲氯芬酯治疗急性脑出血的临床疗效和安全性。方法:266例经头颅CT确诊为急性脑出血的病人被随机分为两组:治疗组136例和对照组130例。治疗组是在对照组基础上加用盐酸甲氯芬酯0.25 g(加入0.9%氯化钠溶液250 mL中)静脉滴注,1次/d,14 d为一个疗程。结果:在治疗后第7、14、28天,治疗组病人的美国国立卫生研究院卒中量表(NIHSS)评分和Glasgow昏迷评分的改善分值和改善率均有明显好转,与对照组相比有显著性差异(P<0.05),且治疗组的总有效率均显著高于对照组(P<0.05)。两组不良事件总的发生率无显著性差异(P>0.05)。结论:盐酸甲氯芬酯能改善急性脑出血病人的神经功能缺损和意识障碍水平,是一种治疗急性脑出血安全、有效的药物。Objective： To evaluate the efficacy and safety of meclofenoxate hydrochloride in treatment of patients with acute intracerebral hemorrhage. Methods： Two hundred and sixty-six patients with acute intracerebral hemorrhage diagnosed by CT were included in the trial. The patients were randomly assigned to two groups. Patients in the treatment group （n=136） were given 250 mL of 0. 9% sodium chloride injection containing meclofenoxate hydrochloride 0. 25 g daily for 14 days in combination with the routine therapy, while patients in the control group （n = 130） were treated routinely alone without meclofenoxate hydrochloride. Results： The improvement rates and scores of the National Institutes of Health Stroke Scale and Glasgow coma scale in the treatment group evaluated on clays 7, 14 and 28 were significantly better than those in the control group （P〈0. 05）. The total effective rates in the treatment group on days 7,14,28 were significantly higher than those in the control group （P〈0.05）. There was no statistically significant difference in the total incidence of adverse drug reactions in the two groups （P〉0.05）. Conclusion： Meclofenoxate hydrochloride,which is effective and safe in the treatment of acute intracerebral hemorrhage, can improve the levels of neurological impairment and consciousness of the patients.

关 键 词：脑出血 甲氯芬酯 临床对照试验 

分 类 号：R743.34[医药卫生—神经病学与精神病学] R909.4[医药卫生—临床医学]