志贺菌群及其血清型14年的变化和耐药趋势  

Variability and antimicrobial resistant tendency of Shigella spp. groups and serotypes in diarrhea patients during 14 years

作　　者：曲芬[1] 崔恩博[1] 郭桐生[1] 刘立明[1] 李筱涵[1] 鲍春梅[1] 毛远丽[1] 

机构地区：[1]解放军第三○二医院,北京100039

出　　处：《传染病信息》2007年第4期223-225,229,共4页Infectious Disease Information

摘　　要：目的监测我院1993-2006年与腹泻有关志贺菌群及其血清型14年的变化和耐药趋势，为本地区的流行病学研究、疫苗的制备及临床合理用药提供依据。方法通过常规大便培养，筛出致病菌后经生化及血清学进一步鉴定到种、群或血清型，并以纸片扩散法测定了抗菌药物的敏感性。结果14年分离到志贺菌6739株，患者以男性青年为主，6-9月份为腹泻发病高峰。共检测到志贺菌的4个群23个血清型。B群最多，占75．86％；D群占23．82％，有明显增多的趋势；F2a、F4和Fx分别占73，5％、5，6％和4．5％。各菌种及不同的血清型对抗菌药物的敏感率有差异，B群多重耐药较多。结论志贺菌群及血清型种类多，随时间的变迁变化明显，耐药性不同，应重视监测。Objective To monitor the variability and drug resistant tendency of Shigella spp. groups and serotypes in diarrhea patients in our hospital from 1993 to 2006 to offer the evidences for epidemiological study, vaccination research and clinical treatment. Methods Shigella spp. were cultured in stool samples, then groups and serotypes of Shigella spp. were identified with the biochemical and serologic test. The susceptibility of Shigella to antimicrobial agents was tested with Kirby-Bauer. Results A total of 6 739 isolates were identified during the 14 years. Diarrhea was most likely to occur in young men from June to September. Four groups and 23 serotypes were detected, among which group B accounted for 75.86%, group D 23.82% with an enhancive tendency and serotype F2a,F4 and Fx 73.5% ,5.6% and 4.5%, respectively. There was a difference in the sensitive rate of different groups and serotypes to antimicrobial agents. Group B was resistant to multiple antibiotics. Conclusion Importance should be attached to supervise Shigella spp. groups and serotypes, for they are plenty and have changed a lot with years, moreover they have different drug resistances.

关 键 词：病原菌 腹泻 分布 耐药性 

分 类 号：R574.62[医药卫生—消化系统]