P糖蛋白与乙型肝炎病毒X蛋白在肝癌原发灶和门静脉癌栓中的表达及其临床意义  

EXPRESSION OF P-GLYCOPROTEIN(PGP) AND HEPATITIS B VIRUS X PROTEIN IN THE PRIMARY TUMOR OF LIVER CNACER AND PORTAL VEIN CANCER EMBOLUS AND ITS CLINICAL SIGNIFICANCE

作　　者：杨盛力[1] 张万广[1] 陈孝平[1] 彭静[1] 刘利平[1] 靖凯[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院,武汉430030

出　　处：《肝胆外科杂志》2007年第4期302-305,共4页Journal of Hepatobiliary Surgery

摘　　要：目的探讨P糖蛋白与乙型肝炎病毒X蛋白肝癌原发灶和门静脉癌栓中的表达及其临床意义。方法采用免疫组化染色法检测36例肝癌原发灶及相应转移灶中P糖蛋白和乙型肝炎病毒X蛋白的表达。结果在肝癌原发灶及其转移灶中,P糖蛋白表达的吸光度值分别为0.247±0.060,0.251±0.071。P糖蛋白在肝癌原发灶和转移灶之间的表达并无显著性差异(P>0.05)。且P糖蛋白的表达同乙型肝炎病毒X蛋白的表达呈正相关(γ=0.911,P<0.05)。结论乙型肝炎病毒X蛋白与肝癌化疗耐药密切相关;P糖蛋白在肝癌原发灶和转移灶之间的表达具有较高的一致性,可以通过检测门静脉癌栓中P糖蛋白的表达,预测肝癌原发灶及其他转移灶对化疗药物的耐药性,为肝癌的个性化化疗提供较好的参考依据。Objective To study the expression of P-glycoprotein （Pgp） and hepatitis B virus x protein in the primary tumor of liver cancer and portal vein cancer embolus and its clinical significance. Method The expression of P-glycoprotein and hepatitis B virus x protein in the primary tumor and their metastases was studied by immunohistochemistring 36 cases of patients with liver cancer. Result The absorption value of P - glycoprotein expression in primary tumor and its metastasis of liver cancer were0. 2466 ± 0. 0597, 0. 2507 ±0. 0712 respectively（ P 〉 0. 05 ）. And the expression of Pgp was positively correlated with the expression of hepatitis B virus x protein （y = 0. 911 ,P 〈 0. 05）. Conclusion Hepatitis B virus x protein is closely correlated with the chemotherapy resistance of liver cancer; there is a high consistency in expression of Pgp between the primary tumor of liver cancer and portal vein cancer embolus, so we can predict the resistance to chemotherapy drugs in primary tumor and other metastases of liver cancer through detecting the expression of P-glycoprotein in portal vein thrombosis, providing a better reference for the individualized chemotherapy.

关 键 词：P糖蛋白 乙型肝炎病毒X蛋白 肝癌 原发灶 门静脉癌栓 多药耐药 

分 类 号：R735.7[医药卫生—肿瘤]