BSAP MUM1在经典型霍奇金淋巴瘤的表达及意义  

The expression and significance of BASP and MUM1 in classical hodgkin lymphoma

作　　者：郗彦凤[1] 徐恩伟[1] 白文启[2] 王晋芬[1] 孙瑞芳[1] 

机构地区：[1]山西省肿瘤医院病理科,太原030013 [2]山西省肿瘤医院肛肠科,太原030013

出　　处：《中国药物与临床》2007年第9期670-671,共2页Chinese Remedies & Clinics

基　　金：山西省青年基金资助项目(20051051)

摘　　要：目的探讨BSAP、MUM1在经典型霍奇金淋巴瘤的表达情况。方法对81例经典型霍奇金淋巴瘤应用免疫组织化学Envision二步法进行BASP、MUM1、BCL-6、CD10、CD3、CD20、CD15、CD30的标记。结果CD3、BCL-6、CD10全部阴性,BASP、MUM1、CD20、CD15、CD30的阳性率分别为58.02%、100%、7.41%、59.26%、100%。结论经典型霍奇金淋巴瘤的H/RS细胞起源于生发中心后期分化的B细胞,它是一种活化的B细胞。Objective To investigate the expressions of BSAP and MUM1 in classical Hodgkin＇s lymphoma （CHL）. Methods The expressious of BSAP. MUM1, CD3, CD20, CD15 and CD30 were assessed with two-step Envision method in 81 patients with CHL. Results In all cases, expressions of CD3, BCL-6 and CDIO were negative, whereas the positive rate of BSAP, MUM1, CD20, CDI5 and CD30 were 58.02%, 100%, 7.41%, 59.26% and 100^, respectively. Conclusion The H/RS cells of classical Hodgkin＇s lymphoma appear to be derived from a later stage of germinal center B cells, and therefore, are activated B cells.

关 键 词：B淋巴细胞 经典型霍奇金淋巴瘤 H/RS细胞 B细胞特异性激活蛋白 MUMI 

分 类 号：R733.1[医药卫生—肿瘤]