中枢神经系统黑色素细胞病变的临床与病理特征  

Clinical and pathologic features of melanocytic lesion of the central nervous system

作　　者：张宁[1] 刘尊敬[2] 李刚[1] 肖波[1] 刘运海[1] 李国良[1] 吕冰清[1] 梁静慧[1] 

机构地区：[1]中南大学湘雅医院神经内科,长沙410008 [2]中日友好医院神经内科,北京100029

出　　处：《中南大学学报（医学版）》2007年第4期713-717,共5页Journal of Central South University ：Medical Science

摘　　要：目的:探讨中枢神经系统黑色素细胞病变的临床与病理特征。方法:分析2例神经皮肤黑色素沉着症(NCM)和4例原发性脑膜黑色素瘤(PLM)患者的临床表现、影像学资料及术中与病理所见。结果:6例患者均以颅高压、癫痫为主要临床特征,CT或MRI有不同程度异常发现;2例NCM自出生后即有全身皮肤多处大片黑色素痣;4例PLM则无皮肤色素沉着及黑色斑块,其脑组织病理报告均发现脑膜黑色素瘤细胞。结论:颅高压、癫痫性发作是中枢神经系统黑色素细胞病变主要临床表现,皮肤损害、影像学改变对诊断有重要价值。Objective To investigate of the central nervous system. Methods the clinical and pathologic features of melanocytic lesion We analyzed the clinical features, neuroimagings, and operational and neuropathological findings of 2 patients of neurocutaneous melanosis and 4 patients of primary leptomeningeal melanoma. Results All the 6 patients had the common clinical features of intracranial hypertension and epilepsy. Brain CT and MRI showed abnormal signals. More melanin pigment nevi were found on the skin of the 2 patients subjected to neurocutaneous melanosis. The other 4 patients subjected to primary leptomeningeal melanoma had no melanin pigment nevus on the skin, but the brain section displayed positive meningeal melanoma. Conclusion Intracranial hypertension and epilepsy are the main clinical manifestations of melanocytic lesion of the central nervous system, and cutaneous lesion and radiological findings are very important for the diagnosis.

关 键 词：神经皮肤黑色素沉着症 原发性脑膜黑色素瘤 临床表现 病理检查 

分 类 号：R739.4[医药卫生—肿瘤]