兔胆红素钙结石成石过程中免疫复合物存在的意义  

The Significance of Immune Complexes in Serum and Bile in the Formation of Calcium Bilirubinate Gallstones in Rabbits

作　　者：曾勇[1] 肖路加[1] 

机构地区：[1]华西医科大学附一院肝胆外科

出　　处：《华西医学》1997年第1期94-95,共2页West China Medical Journal

摘　　要：对正常对照组（Ｃｏｎ组，ｎ＝１０），胆道单纯不全梗阻组（ＢＯ组，ｎ＝４５）和胆道不全梗阻加感染组（ＢＯＩ，ｎ＝４５）兔的血清和胆汁中免疫复合物（ＩＣ）进行了动态对比研究。结果发现ＢＯ组和ＢＯＩ组早期血清和胆汁中均未见ＩＣ的存在，随着成石率的逐步增加，ＩＣ的阳性率明显增高（Ｐ＜０．０５）。结果提示：在色素石形成过程中血清、胆囊和胆管胆汁均有ＩＣ的存在，为特异性抗原与Ｉｇ结合所致。ＩＣ的存在不是致石的直接原因，但促进了结石的形成。The dynamic comparative study of immune complexes (IC)in serum and bile was carried out in 3 groups of rabits under different conditions,as partial biliary obstruction(BO,n=45),partial biliary obstruction with infection(BOI,n=45)and normal rabbits(n=10)as control(Con).It was discovered that in the early stage,IC was not discovered in serum or bile of either group.With the increase incidence of gallstone formation,the postive rate of IC was increased remarkably(p<0 05).The experiment suggested during formation of pigmented gallstones,IC was existed in both serum and bile.The existence of IC was not directly responsible for the formation of gallstones,but IC in serum and bile may enhance are formation of gallstones.

关 键 词：胆红素钙结石 免疫复合物 胆结石 病因 

分 类 号：R575.620.2[医药卫生—消化系统]