口腔扁平苔藓组织中p73和COX-2表达的临床意义  

The expression and significance of p73 and COX-2 in oral lichen planus

作　　者：漆明[1] 张敬[1] 韩恩善[2] 

机构地区：[1]宁夏医学院附属医院口腔科,宁夏银川750004 [2]宁夏医学院附属医院病理科,宁夏银川750004

出　　处：《中国医师杂志》2007年第8期1012-1014,共3页Journal of Chinese Physician

基　　金：宁夏自然科学基金资助项目（NZ0548）

摘　　要：目的探讨p73、COX-2在口腔扁平苔藓恶变过程中表达的意义。方法采用免疫组化方法，检测口腔扁平苔藓组织中p73、COX-2的表达情况，采用Image Plus 5.0专业图像分析软件进行IOD值（累计光密度值）的测量。结果p73、COX-2的阳性表达从正常口腔黏膜到口腔扁平苔藓再到口腔鳞状细胞癌这一过程中均呈逐渐增高的趋势，各指标的IOD值均有统计学意义（P〈0.05），p73、COX-2表达的IOD值强度与癌组织的分化程度相关。p73、COX-2在口腔扁平苔藓、正常口腔黏膜、口腔鳞状细胞癌组织中的表达均有相关性（P〈0.05）。结论p73、COX-2在口腔扁平苔藓恶变过程中起到一定作用，检测这两个指标对OLP的癌变具有一定的早期诊断和预测价值。Objective To explore the significance of p73 and COX-2 in the progress of oral lichen planus evolved into oral squamous cell carcinoma. Methods ： The expression of p73 and COX-2 was detected by immunihistochemisty in oral lichen planus. The results were analyzed by the software Image Plus 5.0. Results The expression of p73 and COX-2 increased significantly as the progression of oral mucosa from normal to oral lichen planus and oral SCC. The intensity of p73 and COX-2 expression was correlated with histological grade. The expression of p73 and COX-2 in normal oral mucosa, oral lichen planus and oral SCC were significantly correlated （ P 〈 0. 05）. Conclusions Carcinogenesis of oral lichen planus is a continuous and stepwise course, p73 and COX-2 genes may play an important role in the disease.

关 键 词：扁平苔癣 口腔 前列腺素内过氧化物合酶 基因 肿瘤抑制 

分 类 号：R78[医药卫生—口腔医学]