EZH2在原发性肝细胞性肝癌中的表达及其临床意义  

The expression and clinic significance of EZH2 protein in primary human hepatocellular carcinoma

作　　者：康凯夫[1] 车爱文[1] 石祥呈[1] 谭光明[1] 剧永乐[1] 康子婧[1] 

机构地区：[1]广东省佛山市顺德区第一人民医院病理科,广东顺德528300

出　　处：《中国医师杂志》2007年第8期1030-1032,共3页Journal of Chinese Physician

摘　　要：目的探讨果蝇zeste基因增强子同源物2（EZH 2）蛋白在原发性肝细胞性肝癌（HCC）中的表达状况及其临床意义。方法应用免疫组化S-P法检测原发性肝细胞性肝癌50例、肝硬化30例、正常肝组织9例中EZH2蛋白的表达。结果EZH2蛋白主要表达于细胞核，原发性肝细胞性肝癌、肝硬化和正常肝组织的EZH2蛋白阳性表达率分别是88.00%（44/50）、46.67%（14/30）、33.33%（3/9），且EZH2蛋白在原发性肝细胞性肝癌组织中的表达明显高于在肝硬化和正常肝组织中的表达（χ2=16.07，10.09，P〈0.01）。结论EZH2异常表达与原发性肝细胞性肝癌的发展密切相关，在原发性肝细胞性肝癌的发展过程中起重要的作用。Objective This study is to explore the expression and clinic significance of EZH2 （enhancer of zeste homolog 2） protein in human primary hepatocellular carcinoma. Methods The expressions of EZH2 protein in 50 cancer tissues, 30 cirrhosis tissues and 9 normal tissues were assessed by immunohistochemical method. Results The expressions of EZH2 protein was located at nucleus. The rate of expressions of EZH2 protein in cancer tissues, cirrhosis tissues, normal tissues were 88. 00% （44/50） ,46. 67 % （ 14/30）, 33.33% （3/9） respectively. The expressions of EZH2 protein in cancer tissues was higher than that in cirrhosis tissues and normal tissues（ x^2 = 16. 07, 10.09, P 〈 0. 01 ）. Conclusion The abnormal expression of EZH2 are closely associated with the development of human primary hepatocellular carcinoma, which may play an important role in the development of primary human hepatocellular carcinoma.

关 键 词：癌 肝细胞 果蝇属 基因 

分 类 号：R735[医药卫生—肿瘤]