Survivin在不同腺管开口大肠病变中的表达及意义  

Expression and clinical significance of Survivin in different pit pattern of colorectal lesions

作　　者：卢笛[1] 付云辉[2] 袁伟建[2] 

机构地区：[1]湖南省人民医院消化内科,湖南长沙410005 [2]中南大学湘雅医院消化内科

出　　处：《中国医师杂志》2007年第8期1033-1035,共3页Journal of Chinese Physician

摘　　要：目的探讨大肠黏膜病变腺管开口分型对大肠肿瘤或非肿瘤性增生性病变的诊断价值；比较不同腺管开口分型中Survivin蛋白的表达及其与大肠组织异常增殖的关系。方法采用内镜下黏膜染色结合放大内镜法观察72例大肠黏膜病变腺管开口分型，据Kudo分型判断病变的肿瘤或非肿瘤性，对照病理诊断，比较两种诊断方法的一致性。用SP免疫组化方法检测上述病变中的Survivin蛋白的表达，比较大肠病变腺管开口类型与其表达关系。结果大肠病变腺管开口分型对非瘤性病变诊断敏感性为87.5%，特异性为95.5%；对腺瘤性病变诊断敏感性达97.1%；特异性为91.9%。随着大肠病变腺管开口分型序数升高，Survivin蛋白的表达率也呈递增趋势。结论染色放大内镜下大肠黏膜病变腺管开口对区分肿瘤性与非肿瘤性病变与病理诊断具有高度一致性。Survivin基因表达是大肠癌的发生进程中早期事件。Objective To discuss the diagnostic value of pit pattern classification of colorectal mucosa by endoscope on neoplastic or non - neoplastic colorectal lesions, and explore the molecular mechanism of disease by comparing the expression of Survivin protein in different pit pattern colorectal lesions. Methods 72 cases of colorectal mucosal lesions were observed by mucosal staining technology combined with magnifying endoscope, differentiating the neoplastic from non - neoplastic lesions according to Kudo criteria, and endoscope diagnosis with pathological diagnosis to find the correlation between the two methods were compared. Survivin protein expression was detected by SP immunohistochemical, and then the expression of Survivin protein in different pit pattern of colorectal lesions was compared. Results Diagnostic specificity of non - neoplastic lesions diagnosed by magnifying chromonendoscope was 95.5% , diagnostic specificity of neoplastic lesions dignosed by endoscope was 94.0%. The positive rate of the expression of Survivin protein increased from type Ⅰ to type Ⅴ. Conclusions Examination the nature of colorectal lesions on the basis of pit pattern classification by using endoscope diagnosis had a high coherence with pathological diagnosis. Survivin protein can be used as a molecular marker of colorectal cancer in the early stage.

关 键 词：微管相关蛋白质类 肠肿瘤 

分 类 号：R735[医药卫生—肿瘤] R57[医药卫生—临床医学]