老年白血病38例临床分析  

Leukemia in the elderly patients clinical analysis of 38 cases

作　　者：翁巍[1] 孙致信[1] 

机构地区：[1]上海市长宁区中心医院血液内科,上海200336

出　　处：《安徽医药》2007年第9期822-824,共3页Anhui Medical and Pharmaceutical Journal

摘　　要：目的分析老年白血病的临床特点,探讨合理治疗与预后。方法总结38例老年白血病,急性白血病(AL)23例,慢性及特殊类型白血病15例,按个体差异采用小剂量化疗、标准剂量化疗和姑息治疗。结果AL完全缓解(CR)率38.9%,慢性及特殊类型白血病CR率40%,两组差异无显著性(P=0.505)。AL化疗组的CR率和中位生存时间高于姑息治疗组(P<0.05)。小剂量化疗的生存时间高于标准剂量组(P<0.05)。高LDH组的CR率低于正常LDH组(P<0.05)。结论老年白血病对化疗耐受差,生存期短,缓解率低,死亡率高。应强调个体化治疗。Aim To analyse the clinical characteristics of leukemia in old patients and discuss the rational therapy and prognosis. Methods 38 oldpatients with leukemia were studied,23 acute leukemia （AL） , 15 chronic and especially leukemia 33 patients were treated with individualized low dose chems,standard dose chems and palliation care. Results Complete remission （CR） rate of AL was 38. 9%. CR rate of chronicity and especially leukemia was 40% （ P = 0. 505 ）. CR rate and median survival time of chems group were higher than palliation care group（ P 〈0.05 ）. Median survival time of low dose chems group were longer than that of standard dose group（P 〈 0.05 ）. CR rate of high Serum LDH level group was lower than that of the normal group（P 〈 0.05 ）. Conclusion The treatment strategy of elderly patients with leukemia should be made individually. Their response to the chemotherapy is poor,overall survival phase is shorter,remission rate is lower,and mortality is higher.

关 键 词：白血病 疗效 老年人 临床病例分析 

分 类 号：R733.7[医药卫生—肿瘤]