非小细胞肺癌患者血清中TGF-β_1测定及其临床意义探讨  

Detection of serum TGF-β_1 in patients with non-small-cell lung cancer

作　　者：郭秀娟[1] 张金忠[1] 张金艳[1] 郑金秀[1] 魏媛媛[1] 

机构地区：[1]河北医科大学第四医院免疫室,石家庄市050011

出　　处：《河北医药》2007年第8期794-795,共2页Hebei Medical Journal

基　　金：河北省科技攻关计划项目(编号:072761217)

摘　　要：目的探讨非小细胞肺癌(NSCLC)患者血清中TGF-β1在放疗前后浓度变化及其临床意义。方法采用酶联免疫吸附实验测定34例NSCLC患者放疗前后TGF-β1水平,并与正常对照组进行比较分析。结果NSCLC患者血清TGF-β1水平较正常人明显增高(P<0.01)。同一NSCLC患者放疗前后血清TGF-β1水平有明显差异(P<0.01)。放疗后NSCLC患者发生放射性肺炎的患者血清中TGF-β1放疗后与放疗前的比率高于完全缓解和部分缓解的患者(P<0.05)。结论NSCLC患者血清TGF-β1水平增高可能与疾病的发生发展有关。血清TGF-1β可作为NSCLC患者辅助诊断和疗效观察指标之一。Objective To investigate the change and clinicalmeaning of transforming growth factor β1 （TGF-β1） in patients with non-small-cell lung cancer（NSCLC） before and after radiotherapy. Methods the levels of serum TGF-β1 in 34 patients with NSCLC were detected by ELISA , the data were analyzed and compared withthose of control group. Results The content of TGF-β1 in serum of NSCLC patients was significantly higher than that of control group（ P 〈 0.01）.There was a significant difference in the content of TGF-β1 in the same patient with NSCLC before radiotherapy and after radiotherapy （ P 〈0.01）. The ratio of TGF-β1 after radiotherapy and before radiotherapy in the patients who were effectively treated was effective was significantly different, as comparedwith that in the patients who had radiation induced pneumonia after radiotherapy（ P 〈 0.05）. Conclusion Higher levels of serum TGF-β1 may be related to the pathogenesis and developmentof the disease, and serum TGF-β1 could be used as one of diagnostic and efficacy observation indicators in patients with NSCLC.

关 键 词：TGF-Β1 非小细胞肺癌 酶联免疫吸附实验 

分 类 号：R575.2[医药卫生—消化系统]