t-PA,PAI-1在脑梗死、脑出血病患者中的检测及临床意义  

Tissue-type Plasminogen Activator and Plasminogen Activator Inhibitor-1 in Cerebral Infarction and Cerebral Hemorrhage and Its Clinical Significance

作　　者：丁元深 葛梅 刘贤忠[2] 牟青杰[2] 

机构地区：[1]五莲县人民医院内科,山东五莲262300 [2]潍坊医学院外科学教研室

出　　处：《潍坊医学院学报》2007年第4期301-303,共3页Acta Academiae Medicinae Weifang

摘　　要：目的研究纤溶指标组织型纤溶酶原激活物(t-PA)、纤溶酶激活物抑制物-1(PAI-1)抗原含量在脑梗死(C I)、脑出血(CH)患者血浆中治疗前后的变化及其临床意义。方法用酶联免疫吸附双抗体夹心法(ELISA)分别检测30例C I、20例CH患者血浆t-PA PAI-1的抗原含量水平治疗前后的含量变化。结果①与对照组比较:C I患者组t-PA、PAI-1抗原含量水平均高于对照组(P<0.05);CH组t-PA高于对照组(P<0.05),PAI-1低于对照组(P<0.05)。②治疗后的比较:血浆t-PA水平在C I和CH两组治疗前、后的变化均无统计学意义(P>0.05);血浆PAI-1抗原含量在C I组患者治疗后明显低于治疗前(P<0.05),而在CH组患者治疗后是增高的(P<0.05),治疗后两组的PAI-1抗原含量水平均与对照组无差异。结论t-PA抗原含量水平在脑梗死组、脑出血组患者均升高。PAI-1抗原含量水平在脑梗死组患者升高,在脑出血组降低,可作为判断病情严重程度、预后与复发及判断病程、病期的参考指标。Objective To study the clinical significance of plasma levels of tissue-type plasminogen activator（t-PA） and plasminogen activator inhibitor-1 （ PAI-1 ） in patients with cerebral infarction （ CI ） and cerebral hemorrhage （ CH ）. Methods Fibrinolysis markers of t-PA and PAI-1 in plasma of 30 cases of cerebral infarction （CI） ,20 cases of cerebral hemorrhage （ CH ） patients before and after treatment were tested by Enzyme-linked immunosorbent assay（ ELISA ） , and compared with control group. Results Compared with the contrel group,the plasma level of markers t-PA and PA1-1 both increased significantly in group of CI （ P 〈 0.05 ）, t-PA increased （ P 〈 0.05 ） in group of CH while PAI-1 decreased （ P 〈0.05 ）. After treatment,the plasma level of t-PA had no significant difference in both groups （ P 〉 0.05 ）. The plasma level of PAI-1 degraded in group of CI （ P 〈 0.05 ） while rose in group of CH （ P 〈 0.05 ） ,and compared with contrel group, the difference of PAI-1 in both groups was not significant. Conclusion The plasma level of t-PA increased significantly in all patients. The plasma level of PAI-1 increased in group of CI but decreased in group of CH. t-PA and PAI-1 are important indexes that correlate with fibrinolysis markers in vivo. They can be used as the quick and cheap referent indexes to identify cerebral infarction （CI） and cerebral hemorrhage （ CH） ,and to evaluate patient＇s prognosis,recurrence,course and stage of disease.

关 键 词：血浆组织型纤溶酶原激活物 纤溶酶激活物抑制物-1 脑出血 脑梗死 

分 类 号：R743[医药卫生—神经病学与精神病学]