抑郁症患者的血清叶酸和维生素B_(12)浓度测定及其临床意义  

Test of serum folic acid and vitamin B_(12) levels of patients with depression

作　　者：倪苏琳[1] 袁勇贵[1] 周娟[2] 方群[1] 

机构地区：[1]南京医科大学脑科医院,南京210029 [2]淮安市第三人民医院

出　　处：《中国民康医学》2007年第17期719-720,共2页Medical Journal of Chinese People’s Health

基　　金：南京市医学科技发展项目资金资助(项目编号:YKK0351)

摘　　要：目的:探讨抑郁症患者与血清叶酸和维生素B12浓度的关系。方法:采用放射免疫法对29例抑郁症患者(老年期抑郁症患者11例、青年抑郁症患者18例)和42例正常人(正常老年人20例、正常青年人22例)的血清叶酸和维生素B12浓度进行测定。结果:老年期抑郁症患者的血清叶酸浓度[(13.55±3.80)ng/ml]显著低于正常老年人[(18.86±7.99)ng/ml](P<0.05),血清维生素B12浓度与正常老年人差异无显著性(P>0.05);青年抑郁症患者的血清叶酸[(12.20±4.17)ng/ml]和维生素B12浓度[(309.02±101.57)pg/ml]显著低于正常青年人[(20.11±10.59)ng/ml]和[(428.66±145.13)pg/ml](P均<0.05)。抑郁症患者的HAMD评分与血清叶酸和维生素B12浓度均无显著相关性(P均>0.05)。结论:抑郁症患者存在叶酸和维生素B12缺乏。Objective：To explore the relations of serum folic acid and vitamin B12 levels in patients with depression. Methods： The blood preparation of 29 patients with depression （11 aged people, 18 youth） and 42 healthy adults （20 aged people, 22 youth） were collected. Serum folic acid and vitamin B12 levels were examined by radio - immunization for all the subjects. Results： In aged people, The average Serum folic acid level in the depression group[ （ 13.55 ± 3.80） ng/ml] was significantly lower than the control group [ （ 18.86 ± 7.99） ng/ml ] P 〈 0.05, and there was not statistically significant differences in serum vitamin B12 level between two groups （ P 〉 0.05 ） . In youth, The average Serum folic acid [ （ 12.20 ± 4.17 ） ng/ml ] and vitamin B12 level [ （ 309.02 ± 101.57 ） pg/ ml] in the depression group were significantly lower than the control group[ （20.11 ±10.59） ng/ml and （428.66 ±145.13）pg/ml, P 〈 0.05 ] respectively. Conclusions： Depression has some relationship with vitamin B12 and folic acid.

关 键 词：抑郁症 叶酸 维生素B12 

分 类 号：R749.41[医药卫生—神经病学与精神病学]