口腔颌面部大型静脉畸形86例临床分析  

Clinical Analysis of Venous Malformations in Maxillofacial Region with 86 Cases

作　　者：曾满堂[1] 杜国强[2] 刘金兵[3] 

机构地区：[1]怀化市第五人民医院口腔科,湖南省怀化市418000 [2]郑州铁路职业技术学院外科教研室,河南省郑州市450052 [3]湖南大学湘雅二医院口腔医疗中心,湖南省长沙市410012

出　　处：《组织工程与重建外科杂志》2007年第4期205-206,221,共3页Journal of Tissue Engineering and Reconstructive Surgery

摘　　要：目的探讨应用平阳霉素(PYM)、鱼肝油酸钠(SM)、地塞米松(DXM)联合病变内注射治疗口腔颌面部大型静脉畸形的临床疗效。方法选择86例口腔颌面部大型静脉畸形,病灶范围在5cm×3cm至10cm×7cm之间,取DXM5mg/ml,PYM 8mg,配1%普鲁卡因4ml及生理盐水3ml,按病变面积每1cm×1cm注射混合药物1ml计算注射剂量,再按相对大剂量鱼肝油酸钠注射方法注射鱼肝油酸钠。每隔7～10d注射1次,3～6次为1个疗程。未愈者可重复注射治疗。结果经6～48个月随防,治愈45例(52.3%),基本治愈32例(37.2%),好转9例(10.5%)。结论PYM、SM、DXM联合病变内注射治疗口腔颌面部大型静脉畸形,治愈和基本治愈率达89.5%,有效率为100%,临床疗效肯定、安全,疗程较短,为治疗口腔颌面部大型静脉畸形的一种比较理想的方法,值得推广应用。Objective To explore the clinical effect of combining injection with PYM, SM and DXM in venous malformations of maxillofaeial region. Methods Focus diameter ranged 5 cm× 3 cm × 10 cm × 7 cm. DXM 5 mg/ml and PYM 8 mg were mixed with 1% procaine and normal saline 3 ml. Each focus of 1 cm × 1 cm was injected 1 ml of compound liquid. Patients were treated 3-6 cycled with 7-10 d interval between each cycle. Results Of 86 cases, 45 cases were completely cleared （52.3 %）, 32 cases were significantly improved （37.2 %） and 9 cases were moderately improved （10.5 %） in followed up for 6-48 months. Conclusion Combining injection of PYM, SM and DXM in focus is effective and safe enough for the treatment of venous malformations on maxillofaeial region.

关 键 词：大型静脉畸形 口腔颌面部 平阳霉素 鱼肝油酸钠 地塞米松 

分 类 号：R739.81[医药卫生—肿瘤]