左卡尼汀治疗老年慢性心力衰竭的疗效和安全性  

Efficacy and safety of L-carnitine in treatment of aged patients with chronic heart failure

作　　者：陈朝婷[1] 陈祥华[2] 胡萍[1] 盛净[1] 

机构地区：[1]上海交通大学医学院附属第九人民医院老年科,上海市200011 [2]上海交通大学医学院附属第九人民医院心超室,上海市200011

出　　处：《中国心血管病研究》2007年第9期649-651,共3页Chinese Journal of Cardiovascular Research

摘　　要：目的观察左卡尼汀治疗老年慢性心力衰竭的疗效及安全性。方法老年慢性心力衰竭患者50例,随机均分为2组:对照组和左卡尼汀组,两组均给予常规抗心衰治疗,左卡尼汀组同时给予5%GS250ml加左卡尼汀3g静脉滴注,1次/d,共15d,然后口服左卡尼汀1g/次,2次/d,共15d。结果加用左卡尼汀治疗慢性心功能衰竭总有效率为84.0%,显著优于对照组60.0%(P<0.05),左室收缩功能较常规治疗组有明显改善(P<0.05),未见明显不良反应。结论左卡尼汀治疗老年慢性心力衰竭安全有效、无明显毒副作用。Objective To observe the efficacy and safety of L-Carnitine in the treatment of aged patients with chronic heart failure. Methods 50 patients with chronic heart failure were devided randomly into two groups： controlled group and L-Carnitine group.Both groups received conventional treatment to improve cardiac function. Meanwhile L-Carnitine group received additionally L-Carnitine infusion 3 g in 5% glucose 250 ml everyday,for 15 days,then oral L-Carnitine 2.0 g/d for 15 days. Results L-Carnitine has significantly improved heart disfunction （total efficiency 84.0% vs 60.0% ） and left ventricular systolic function compared with controlled group （P〈0.05）. No side-effect was observed. Conclusion L-Carnitine is an effective and safe drug to improve heart function in aged patients with chronic heart failure patients.

关 键 词：肉碱 心力衰竭 充血性 心室功能 左 治疗结果 

分 类 号：R541.61[医药卫生—心血管疾病]