Development of the Relationship between Angiogenesis and Tumor Dormancy  

作　　者：Yu Zhang GuoWei Che 

机构地区：[1]Department of Cardiovascular Thoracic Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.

出　　处：《Chinese Journal of Clinical Oncology》2007年第4期277-281,共5页中国肿瘤临床（英文版）

基　　金：a grant from the National Natural Science Foundation of China (No.30400199)

摘　　要：Tumor dormancy, a complex and still poorly understood phenomenon, has been defined by the long-term persistence of occult can- cer cells during tumor progression. Recurrence and metastasis may occur just because of an activation of a small portion of the tumor cells. In our view, sustained angiogenesis is considered essential in triggering invasive tumor growth. Here we analyze the correlation between angiogenesis and tumor dormancy, the establishment of tumor dormancy models, the imaging strategies and the new biomarkers for dececting microscopic tumors before or during the angiogenic switch. It imperative to understand the role of an- giogenesis in tumor dormancy, as this will accelerate the development of anti-angiogenesis techniques to induce dormancy and/or eradicate dormant disease.Tumor dormancy, a complex and still poorly understood phenomenon, has been defined by the long-term persistence of occult cancer cells during tumor progression. Recurrence and metastasis may occur just because of an activation of a small portion of the tumor cells. In our view, sustained angiogenesis is considered essential in triggering invasive tumor growth. Here we analyze the correlation between angiogenesis and tumor dormancy, the establishment of tumor dormancy models, the imaging strategies and the new biomarkers for dececting microscopic tumors before or during the angiogenic switch. It imperative to understand the role of angiogenesis in tumor dormancy, as this will accelerate the development of anti-angiogenesis techniques to induce dormancy and/or eradicate dormant disease.

关 键 词：tumor dormancy angiogenic switch tumor dormancy therapy. 

分 类 号：R730.5[医药卫生—肿瘤]