人参皂甙对雄性小鼠骨髓细胞染色体的辐射防护作用  

Radioprotective effect of Ginsenoside on chromosome in bone marrow cells of male mouse

作　　者：刘丽波[1] 李玲[1] 刘鹏来[1] 栗学军[1] 康顺爱[2] 

机构地区：[1]白求恩医大预防医学院劳动卫生教研室 [2]吉林省卫生防疫站

出　　处：《白求恩医科大学学报》1997年第4期348-350,共3页Journal of Norman Bethune University of Medical Science

摘　　要：利用小鼠腹腔注射人参皂甙，观察人参皂甙对Ｘ射线照射小鼠骨髓细胞染色体损伤的防护作用。结果表明，不同浓度的人参皂甙（１２．５～２００ｍｇ／ｋｇ）对０．５ＧｙＸ射线诱发小鼠骨髓细胞染色体畸变具有明显的防护作用，且以５０ｍｇ／ｋｇ防护效果最佳。５０ｍｇ／ｋｇ的人参皂甙对不同剂量（０．５～１．０Ｇｙ）Ｘ射线诱发的小鼠骨髓细胞染色体畸变具有防护作用，可使Ｘ射线诱发的染色体畸变率、细胞畸变率明显降低。为此，我们认为ＧＳ对小鼠骨髓细胞染色体具有保护作用。Radioprotective effects of GS on chromosome in bone marrow cells of mice were observed in this study.The results were shown as follows:various concentrations of GS (12.5￣200 mg/kg) had obvious protective effects on chromosome aberrations in bone marrow cells induced by 0.5 Gy X-ray,the most effectively protective dose being 50 mg/kg·Fifty GS had protective effect on chromosome aberrations in bone marrow cells exposed to various X-rays doses (0.5￣1.0 Gy),the frequency of chromosome aberrations and aberrant cells were markedly reduced.Our findings suggest that GS has protective effect on chromosome in bone marrow cells of mice.

关 键 词：人参皂甙 X线 骨髓细胞 染色体畸变 防护 

分 类 号：R285.5[医药卫生—中药学]