紫杉醇周剂量治疗激素非依赖性前列腺癌疗效观察  

Efficacy of weekly dose of paclitaxel in the treatment of androgen-independent prostate cancer

作　　者：冀红红[1] 王争信[2] 吴克雄[1] 常丽[1] 

机构地区：[1]新疆维吾尔自治区克拉玛依市中心医院肿瘤内科,834000 [2]新疆维吾尔自治区克拉玛依市中心医院泌尿外科,834000

出　　处：《中国肿瘤临床与康复》2007年第4期346-347,共2页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的 观察紫杉醇周剂量治疗激素非依赖性前列腺癌的疗效和毒副反应。方法 2004年至2006年2月对18例确诊为激素非依赖性前列腺癌患者,采用紫杉醇60 mg/m2,静脉注射,每周1次,连用3周,休息1周,共使用6周。结果 随访截止2006年2月,无失访病例。至随访结束,治疗后15例中9例患者血清前列腺特异性抗原（PSA）值下降（84±22.3）ng/ml,其中5例下降〉50%。PSA改善与临床改善一致。患者临床症状改善或部分改善10例;B超、T或MRI提示前列腺病变较前缩小9例;骨转移病灶好转6例。病变缓解时间5～20个月,平均12个月。其余5例病变继续进展,临床症状、前列腺病灶、PSA等无改善。肿瘤治疗毒性反应可预测,最常见的不良反应为中性粒细胞减少、神经毒性、恶心、脱发、疲乏。结论 本组经紫杉醇周剂量化疗后疗效肯定,且不良反应轻,患者生活质量明显改善,值得扩大病例进一步研究。Objective To evaluate the efficacy and adverse effects of weekly dose of paclitaxel in treatment of androgen-independent prostate cancer. Methods Eighteen patients with androgen-independent prostate cancer reeeived hormone therapy with paelitaxel at a weekly dose of 60mg/m^2,iv, for 3 weeks as 1 course. The next course started after 1 week interval. Results After treatment with weekly dose of paelitaxel,9 of the 15 patients showed a decline in PSA levels to（84 ± 22.3）ng/ml and 5 patients had a 〉 50% or greater decline in PSA level. Clinical symptoms were improved in 10 patients and the nodules of prostate became smaller in 9 patients. Bone metastasis was improved in 6 patients. The major adverse effects of this treatment were myelosuppression,peripheral neuropathy,nausea and alopecia, Conclusion Weekly dose of paclitaxel for treatment enhances the efficacy without obvious toxicity and prolongs survival time. It is worthy of studying in tire future.

关 键 词：前列腺肿瘤 前列腺特异性抗原 抗雄激素 紫杉醇 周给药 

分 类 号：R737.25[医药卫生—肿瘤] R730.58[医药卫生—临床医学]