依班膦酸钠联合放射治疗骨转移癌临床观察  

Clinical study of metastatic bone tumor treated with ibandronate combined with radiotherapy

作　　者：陈强[1] 金大地[1] 史占军[1] 景宗森[1] 

机构地区：[1]南方医科大学南方医院脊柱骨病外科,广州510515

出　　处：《中国肿瘤临床与康复》2007年第4期357-359,共3页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的观察依班膦酸钠联合放射治疗骨转移癌疼痛的疗效。方法59例骨转移癌患者随机分成观察组(30例)和对照组(29例)。观察组静脉滴注依班膦酸钠4 mg,联合放射治疗40Gy,1个月后再静脉滴注依班膦酸钠4 mg;对照组仅用放疗。结果观察组和对照组止痛有效率分别为90.0%和82.7%(P>0.05),多发骨转移癌观察组与对照组止痛有效率分别为86.7%和51.7%(P<0.05)。随访2个月后观察组与对照组止痛有效率分别为86.6%和62.0%(P<0.05〉。结论依班膦酸钠联合放射治疗骨转移癌疼痛疗效优于单纯放疗。Objective To evaluate the efficacy of ibandronate combined with radiotherapy in treat- ment of pain due to metastatic bone tumour. Methods Fifty-nine patients with metastatic bone tumour were randomly divided into observation group （30 cases） and control group （29 cases）. The observation group was treated with ibandronate（4 mg,iv） combined with radiotherapy （DT 40 Gy ）. Ibandronate was giver 1 month after radiotherapy. The control group was treated with radiotherapy only. Results The effective rates of the observation group and control group were 90.0% and 82.7% , respectively （P 〉 0.05 ）. For pain from multiple loci of bone metastasis tumor,the effective rate of observation group was 86.7% ,while that of the control group was 51.7% （P 〈 0.05）. After two-month follow up,the effective rate of the observation group was 86.6% and that of control group was 63.0% （ P 〈 0.05 ）. Conclusion Ibandronate combined with radiotherapy is effective to relieve pain from metastatic bone tumors, and the side effect was mild.

关 键 词：依班膦酸钠 骨肿瘤/放射疗法 疼痛 

分 类 号：R738.1[医药卫生—肿瘤] R730.53[医药卫生—临床医学]