急性脑梗死患者血清脂联素、瘦素与白细胞介素的动态变化  

Change of adiponectin,leptin and interleukin in serum of acute cerebral infarction

作　　者：徐广印[1] 陈永生[2] 吴青 

机构地区：[1]临沂市人民医院神经内科,山东省临沂276001 [2]临沂市人民医院中心实验室,山东省临沂276001 [3]山东医学高等专科学校医学统计教研室

出　　处：《中华急诊医学杂志》2007年第9期933-935,共3页Chinese Journal of Emergency Medicine

基　　金：山东省2006年科技发展计划项目(2006GG2302034)

摘　　要：目的研究血清脂联素(adiponectin)、瘦素(leptin)与白细胞介素(IL-1、6、8)水平变化在急性脑梗死的临床诊断、治疗、病情转归和判断预后的应用价值。方法以ELISA法分别检测急性脑梗死患者治疗前后以及正常对照组血清瘦素、脂联素及IL-1、IL-6、IL-8含量,并探讨各指标与神经功能缺损的关系。结果急性脑梗死患者治疗前后血清瘦素及IL-1、IL-6、IL-8含量较对照组明显升高(P<0.01),脑梗死治疗后以上各指标明显下降;而血清脂联素结果在治疗前较对照组明显降低(P<0.01),治疗后升高程度与治疗前及对照组差异具有统计学意义(P<0.01)。脑梗死组神经功能缺损程度与各指标变化均呈显著相关(P<0.01)。结论血清脂联素、瘦素及IL-1、IL-6、IL-8含量的变化与脑梗死的临床变化有较密切的关系,可以作为脑梗死病情变化的监测指标和预后判断指标,同时也为在脑梗死发病早期药物治疗开发提供临床实验依据。Objective To study the value of leptin, adiponectin and interleukin （IL-1, IL-6, IL-8） in diagnosis, treatment, and prognosis of cerebral infarction. Method The levels of serum leptin , adiponectin and IL-1, IL-6, IL-8 in acute cerebral infarction before and after treatment were detemained with ELISA as well as in the healthy controls. The relationship between these indices and nerve function injury was studied. Results The levels of serum leptin and IL-l, IL-6, IL-8 in the patients increased significantly, but the controls didn＇t （P 〈 0.01 ）. The levels of serum adiponectin decreased significantly before treatment was detemained. After treatment was detemained, all the indicies increased significantly. There was significant difference between the indicies and scores of nerve function injury （ P 〈 0.01 ）. The levels of serum adiponectin was negatively correlated with the concentration of leptin and IL-1, IL-6, IL-8. The levels of serum leptin had positive correlation with IL- 1, IL-6, IL-8. Conclusions The relationship betweenthe senlmadiponectin, leptin, IL-1, IL-6, IL-8 and clinical process of cerebral infarction was close. At the same time, these indices are helpful to treat the patients with anti-adhensive molecules and drug.

关 键 词：脂联素 脑梗死 瘦素 白细胞介素 

分 类 号：R743.33[医药卫生—神经病学与精神病学]