肝癌声像图与DNA倍体型关系的研究  

CELLULAR DNA PLOIDY PATTERNS AND THEIR RELATIONSHIP TO THE SONOGRAPHIC FINDINGS OF THE HEPATOCARCINOMA

作　　者：熊建群 郑宗英[2] 周凯书[2] 李瑞珍[3] 杨元华[4] 李景和[4] 沈明[4] 

机构地区：[1]广州市第二人民医院 [2]湖南医科大学附属湘雅医院超声科 [3]湖南医科大学附三院超声科 [4]湖南医科大学病理教研室

出　　处：《中国现代医学杂志》1997年第1期9-11,共3页China Journal of Modern Medicine

摘　　要：该文应用自动图像分析仪对３５例肝穿刺或手术标本的细胞核ＤＮＡ倍体型及其与声像图之间的关系进行分析。结果表明：异倍体（ＡＮ）发生率在正常组或其余各组间有高度显著性差异（Ｐ＜０．０１）；大肝癌组与小肝癌组间有显著性差异（Ｐ＜０．０５）；但弥漫性肝癌组与小肝癌组及大肝癌组间无显著性差异（Ｐ＞０．０５）。肿瘤的异倍体细胞数在无包膜组、高回声组与有包膜组、低回声组之间有高度显著性差异（Ｐ＜０．０１）；在有癌栓组与小肝癌组之间有显著性差异（Ｐ＜０．０５）；与大肝癌组之间无显著性差异。晕环、后方回声衰减的有无与异倍体细胞数无显著相关（Ｐ＞０．０５）。提示肿块大于３ｃｍ、无包膜、高回声、有癌栓是肿瘤恶性程度较高的超声表现，具有预后诊断价值。DNA ploidy patterns of 35 specimens obtained from liver biopsy or operation were studied by image analysis technology The results showed that the deviation of the rate of aneuploid among what are and between normal control and LHCC, normal control and SHCC, LHCC and SHCC were all statistically significant ( P <0 01 and P <0 05,respectively) However, there was no statistically significant difference among SHCC, LHCC and diffuse HCC ( P >0 05) The correlation between cellular DNA ploidy pattern and sonogram finding was also been studied There was a statistically significant difference in the numbers of aneuploid between the tumors of hyperecho without capsule and those of hypoecho with capsule ( P <0 01), are between the tumors with portal thrombosis and those with SHCC ( P <0 05) However, there was no statistically significant difference between the tumors with portal thrombosis and those with LHCC, and there was no correlation between DNA patterns and other sonogram with respect to halo, echoattenuation, ect ( P >0 05) The authors believe that the those with LHCC of hyperecho without capsule or with portol thrombosis is more malignant, and useful for prognosis

关 键 词：肝肿瘤 超声显像 DNA 图像分析术 

分 类 号：R735.7[医药卫生—肿瘤]