基质金属蛋白酶-9及其组织抑制物-1与颈动脉粥样斑块稳定性相关研究  

Relationship between matrix metalloproteinase-9 and tissue metalloproteinase inhibitor-1 and carotid atheromatous plaque stability

作　　者：高峰[1] 宋水江[1] 吴继敏[1] 闻树群[1] 钟国栋[1] 

机构地区：[1]浙江大学医学院附属第二医院神经内科,浙江杭州310009

出　　处：《中国病理生理杂志》2007年第9期1700-1702,共3页Chinese Journal of Pathophysiology

基　　金：浙江省教育厅基金资助项目(No.20030313)

摘　　要：目的:探讨基质金属蛋白酶-9(MMP-9)、基质金属蛋白酶抑制剂-1(TIMP-1)、MMP-9/TIMP-1与脑梗死患者颈动脉粥样斑块稳定性的相关性。方法:80例动脉粥样硬化性脑梗死患者按TCD微栓子检测结果分为微栓子阴性组70例和微栓子阳性组10例,20例正常人作为对照组,分别测定血浆MMP-9、TIMP-1水平。结果:脑梗死患者血浆MMP-9、TIMP-1水平明显高于正常对照组(P<0.01),相关性分析发现MMP-9水平与TIMP-1水平呈正相关(r=0.76,P<0.01)。MMP-9/TIMP-1比值仅在微栓子阳性组明显增高。结论:血浆MMP-9参与了脑梗死的病理生理过程,血浆MMP-9和MMP-9/TIMP-1与颈动脉粥样斑块的不稳定性呈正相关。AIM： To investigate the correlation between matrix metaUoproteinase -9 （MMP-9）, tissue metalloproteinase inhibitor - 1 （ TIMP - 1 ）, MMP - 9/TIMP - 1 and carotid atheromatous plaque stability in cerebral infarction patients. METHODS： 80 patients with cerebral infarction were categorized as microemboli - negative group （ n = 70） and microemboli - positive group （n = 10）, 20 normal human were served as control group. The MMP -9 and TIMP - 1 levels in plasma were determined by mean of ELISA in 3 groups. RESULTS： The levels of MMP-9 and TIMP -1 in plasma were significantly higher in cerebral infarction patients than those in control group （ P 〈 0. 01 ）. The plasma MMP - 9 content was positively correlated with TIMP - 1 content （r =0. 76,P 〈0. 01 ）. The ratio of MMP - 9/TIMP - 1 increased only in microemboli - positive patients （P 〈 0. 01 ）. CONCLUSION： The results indicate that the plasma MMP -9 participates in pathophysiological process of cerebral infarction. The ratio of MMP - 9/TIMP - 1 shows a close relationship with carotid atheromatous plaque instability.

关 键 词：脑梗塞 颈动脉粥样硬化斑块 明胶酶B 金属蛋白酶1组织抑制剂 

分 类 号：R363[医药卫生—病理学]