非小细胞肺癌中EMMPRIN和HGF的表达及其对淋巴结转移和预后的影响  

Relationship of expression of extracellular matrix metalloproteinase inducer and hepatocyte growth factor with lymphoid metastasis and prognosis in non-small-cell lung carcinoma

作　　者：张惠忠[1] 王梅[1] 魏益平[1] 曹永科[1] 李海刚[2] 陈炬[1] 杨艳旗[1] 华平[1] 吴澄[1] 刘金耿[1] 

机构地区：[1]中山大学附属第二医院心胸外科,广东广州510120 [2]中山大学附属第二医院病理科,广东广州510120

出　　处：《中国病理生理杂志》2007年第9期1716-1719,共4页Chinese Journal of Pathophysiology

基　　金：广州市科委科技攻关引导资助项目(No.02Z3-E0016)

摘　　要：目的:研究细胞外基质蛋白酶诱导因子(EMMPRIN)和肝细胞生长因子(HGF)在非小细胞肺癌(NSCLC)组织中的表达及其临床意义。方法:免疫组织化学方法检测77例NSCLC组织中EMMPRIN与HGF的表达,分析其与患者吸烟情况、肿瘤大小、组织学类型、组织分化程度、淋巴结转移和预后的关系。结果:77例NSCLC组织中EMMPRIN与HGF的阳性表达率分别为68%和44%。EMMPRIN与HGF的表达均与淋巴结转移呈正相关(r=0.371和0.339,P<0.01),与患者术后生存时间呈负相关(P<0.01)。EMMPRIN与HGF的表达均与患者吸烟、肿瘤大小、组织学类型和组织分化程度无关(P>0.05)。EMMPRIN与HGF的表达之间呈正相关(r=0.281,P<0.01)。结论:EMMPRIN和HGF的表达与NSCLC的淋巴结转移和预后密切相关,它们的高表达提示NSCLC患者预后不良。AIM： To investigate the expression of extracellular matrix metalloproteinase inducer （EMMPRIN） and hepatocyte growth factor （HGF） in non -small -cell lung carcinoma （NSCLC） and their relationship with lymphoid metastasis and prognosis. METHODS ： Expression of EMMPRIN and HGF in 77 cases of patients with NSCLC was detected immunohistochemically. The relationship of expression of EMMPRIN and HGF with tumor size, smoking, histological type, differentiation, lymphoid metastasis, clinical stage, and prognosis was analyzed. RESULTS： The expressive rates of EMMPRIN and HGF were 68% and 44%, respectively. The expressions of EMMPRIN and HGF were associated positively with lymphoid metastasis （ r = 0. 371 and 0, 339, P 〈 0. 01 ）, and inversely with survival time （ P 〈 0. 01 ）. No relationship was found between the expression of EMMPRIN, HGF and smoking, tumor size, histological type and differentiation （P 〉0. 05 ）. The expression of EMMPRIN was associated with the expression of HGF in NSCLC. CONCLUSION： The expression of EMMPRIN and HGF is associated with lymphoid metastasis and prognosis in NSCLC. Overexpression of EMMPRIN and HGF implies infavourable prognosis in NSCLC.

关 键 词：肺肿瘤 细胞外基质蛋白酶诱导因子 肝细胞生长因子 淋巴转移 预后 

分 类 号：R734.2[医药卫生—肿瘤]